RhoGDIβ inhibition via miR‐200c/AUF1/SOX2/miR‐137 axis contributed to lncRNA MEG3 downregulation‐mediated malignant transformation of human bronchial epithelial cells
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DOI: 10.1002/mc.23702
Abstract: Nickel pollution is a recognized factor contributing to lung cancer. Understanding the molecular mechanisms of its carcinogenic effects is crucial for lung cancer prevention and treatment. Our previous research identified the downregulation of a long… read more here.
Keywords: mir 137; rhogdi; downregulation; mir 200c ... See more keywords
RhoGDI phosphorylation by PKC promotes its interaction with death receptor p75NTR to gate axon growth and neuron survival
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DOI: 10.1038/s44319-024-00064-2
Abstract: How receptors juggle their interactions with multiple downstream effectors remains poorly understood. Here we show that the outcome of death receptor p75NTR signaling is determined through competition of effectors for interaction with its intracellular domain,… read more here.
Keywords: juxtamembrane domain; phosphorylation; rhogdi; p75ntr ... See more keywords
Abstract 526: NFκB p65 overexpression promotes bladder cancer migration via FBW7-mediated degradation of RhoGDIα protein
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DOI: 10.1158/1538-7445.am2017-526
Abstract: Since bladder cancer (BC) is one of the most lethal urological malignant tumors worldwide, understanding the molecular mechanisms that trigger the migration, invasion and metastasis of BC has great significance in reducing the mortality of… read more here.
Keywords: protein; rhogdi; bladder cancer; fbw7 ... See more keywords