How does the exosite of rhomboid protease affect substrate processing and inhibition?
Sign Up to like & getrecommendations! Published in 2017 at "Protein Science"
DOI: 10.1002/pro.3294
Abstract: Rhomboid proteases constitute a family of intramembrane serine proteases ubiquitous in all forms of life. They differ in many aspects from their soluble counterparts. We applied molecular dynamics (MD) computational approach to address several challenging… read more here.
Keywords: protease; mechanism; rhomboid protease; inhibition ... See more keywords
Role of Lipids in the Reaction Coordinate of GlpG Rhomboid Protease
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.1127
Abstract: Rhomboid proteases function in hydrated lipid membrane environments that can impact significantly the catalytic activity of the enzyme. How lipids participate in the reaction coordinate of rhomboid proteases is, however, unclear. We address this question… read more here.
Keywords: rhomboid protease; reaction coordinate; glpg; reaction ... See more keywords
Dissecting the Side Chain Interaction Energies of the Active Site Hydrogen Bond Network in a Rhomboid Protease GlpG
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.507
Abstract: The intramembrane rhomboid proteases are of particular interest due to their ability to hydrolyze a substrate peptide bond at the active site which is buried within the membrane. The high-resolution structure of the E. coli… read more here.
Keywords: rhomboid protease; protease glpg; bond; active site ... See more keywords
Putative Protein Interactome of the Rhomboid Protease RHBDL4.
Sign Up to like & getrecommendations! Published in 2023 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00680
Abstract: The physiological functions of the rhomboid-related protein 4 (RHBDL4) are emerging, but their molecular details remain unclear. Because increased expression of RHBDL4 has been clinically linked to poorer outcomes in cancer patients, this association urgently… read more here.
Keywords: rhomboid protease; rhbdl4; interactome rhomboid; protein ... See more keywords
Chemical Blockage of the Mitochondrial Rhomboid Protease PARL by Novel Ketoamide Inhibitors Reveals Its Role in PINK1/Parkin-Dependent Mitophagy
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c01092
Abstract: The mitochondrial rhomboid protease PARL regulates mitophagy by balancing intramembrane proteolysis of PINK1 and PGAM5. It has been implicated in the pathogenesis of Parkinson’s disease, but its investigation as a possible therapeutic target is challenging… read more here.
Keywords: ketoamide inhibitors; parl; rhomboid protease; mitochondrial rhomboid ... See more keywords
Haloferax volcanii Proteome Response to Deletion of a Rhomboid Protease Gene.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.7b00530
Abstract: Rhomboids are conserved intramembrane serine proteases involved in cell signaling processes. Their role in prokaryotes is scarcely known and remains to be investigated in Archaea. We previously constructed a rhomboid homologue deletion mutant (ΔrhoII) in… read more here.
Keywords: protease; rhomboid protease; haloferax volcanii; deletion ... See more keywords
Rapid synthesis of internal peptidyl α-ketoamides by on resin oxidation for the construction of rhomboid protease inhibitors
Sign Up to like & getrecommendations! Published in 2021 at "RSC Advances"
DOI: 10.1039/d0ra10614c
Abstract: Rhomboid proteases are intramembrane serine proteases, which are involved in a wide variety of biological processes and have been implied in various human diseases. Recently, peptidyl α-ketoamides have been reported as rhomboid inhibitors with high… read more here.
Keywords: rhomboid protease; rapid synthesis; protease inhibitors; peptidyl ketoamides ... See more keywords
A combination of solid-state NMR and MD simulations reveals the binding mode of a rhomboid protease inhibitor
Sign Up to like & getrecommendations! Published in 2021 at "Chemical Science"
DOI: 10.1039/d1sc02146j
Abstract: Intramembrane proteolysis plays a fundamental role in many biological and pathological processes. Intramembrane proteases thus represent promising pharmacological targets, but few selective inhibitors have been identified. This is in contrast to their soluble counterparts, which… read more here.
Keywords: solid state; protease; state nmr; rhomboid protease ... See more keywords
Erratum for Dhingra et al., “RbdB, a Rhomboid Protease Critical for SREBP Activation and Virulence in Aspergillus fumigatus”
Sign Up to like & getrecommendations! Published in 2019 at "mSphere"
DOI: 10.1128/msphere.00678-19
Abstract: Volume 1, no. 2, e00035-16, 2016, [https://doi.org/10.1128/mSphere.00035-16][1]. This article was published on 2 March 2016 with the second author’s surname misspelled. The byline has been updated in the current version, posted on 20 September 2019.… read more here.
Keywords: dhingra rbdb; rhomboid protease; erratum dhingra; rbdb rhomboid ... See more keywords