Investigating the effect of ribavirin treatment on genetic mutations in Crimean–Congo haemorrhagic fever virus (CCHFV) through next‐generation sequencing
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28548
Abstract: Crimean–Congo haemorrhagic fever (CCHF) is the most widespread tick‐borne viral haemorrhagic fever affecting humans, and yet a licensed drug against the virus (CCHFV) is still not available. While several studies have suggested the efficacy of… read more here.
Keywords: ribavirin; haemorrhagic fever; effect; cchfv ... See more keywords
Ledipasvir/Sofosbuvir: A Review in Chronic Hepatitis C
Sign Up to like & getrecommendations! Published in 2018 at "Drugs"
DOI: 10.1007/s40265-018-0864-z
Abstract: Oral once-daily, fixed-dose, ledipasvir/sofosbuvir (Harvoni®) [± ribavirin] is approved in several countries for the treatment of chronic hepatitis C (CHC) in adults and adolescents aged 12 to read more here.
Keywords: ribavirin; infection; sofosbuvir; ledipasvir sofosbuvir ... See more keywords
Cellular Signaling Analysis shows antiviral, ribavirin-mediated ribosomal signaling modulation
Sign Up to like & getrecommendations! Published in 2019 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2019.104598
Abstract: Abstract As antiviral drug resistance develops and new viruses emerge there is a pressing need to develop strategies to rapidly develop antiviral therapeutics. Here we use phospho-specific flow cytometry to assess perturbations of many different… read more here.
Keywords: ribavirin; antiviral drug; cellular signaling; drug ... See more keywords
Ribavirin sensitizes nasopharyngeal carcinoma to 5-fluorouracil through suppressing 5-fluorouracil-induced ERK-dependent-eIF4E activation.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.04.053
Abstract: Although overexpression of eukaryotic translation initiation factor 4E (eIF4E) is associated with enhanced growth and poor prognosis in nasopharyngeal carcinoma (NPC), the function of eIF4E in NPC response to chemotherapy has not been revealed. In… read more here.
Keywords: ribavirin; eif4e; fluorouracil; activation ... See more keywords
Inhibition of eIF4E signaling by ribavirin selectively targets lung cancer and angiogenesis.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.05.127
Abstract: Although the introduction of immune- and targeted-therapy has improved the clinical response and outcomes, lung cancer remains a therapeutic challenge. Developing new therapeutics is necessary to improve the treatment of lung cancer. Here, we show… read more here.
Keywords: cancer; inhibition eif4e; ribavirin; lung cancer ... See more keywords
Real-world effectiveness and safety of sofosbuvir plus daclatasvir with or without ribavirin for genotype 2 chronic hepatitis C in Taiwan.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Formosan Medical Association = Taiwan yi zhi"
DOI: 10.1016/j.jfma.2018.09.016
Abstract: BACKGROUND AND PURPOSE Sofosbuvir (SOF) and daclatasvir (DCV) treatment achieves excellent efficacy and safety in treating chronic hepatitis C (CHC) with various genotypes. Real world experience of SOF/DCV regimen to treat genotype 2 CHC was… read more here.
Keywords: real world; ribavirin; sof dcv; safety ... See more keywords
High efficacy of Resistance-guided retreatment of HCVpatients failing NS5A inhibitors in real world.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of hepatology"
DOI: 10.1016/j.jhep.2019.06.022
Abstract: BACKGROUND Most hepatitis C virus (HCV) infected patients failing NS5A inhibitors develop resistance-associated substitutions (RASs). Here we report the use of resistance-guided retreatment of patients who failed prior NS5A inhibitor-containing regimens in the GEHEP-004 cohort.… read more here.
Keywords: ribavirin; resistance guided; failing ns5a; report ... See more keywords
Daclatasvir and Sofosbuvir With or Without Ribavirin in Liver Transplant Recipients: A Single-Center Real-World Study.
Sign Up to like & getrecommendations! Published in 2018 at "Transplantation proceedings"
DOI: 10.1016/j.transproceed.2018.02.001
Abstract: BACKGROUND Treatment with direct-acting antiviral drugs in interferon-free regimens is currently recommended for viral hepatitis C recurrence after liver transplantation. There are limited data regarding its results in this population, and no optimal treatment scheme… read more here.
Keywords: real world; ribavirin; treatment; liver transplant ... See more keywords
Ribavirin inhibition of cell-culture infectious hepatitis C genotype 1-3 viruses is strain-dependent.
Sign Up to like & getrecommendations! Published in 2019 at "Virology"
DOI: 10.1016/j.virol.2019.09.014
Abstract: Ribavirin remains relevant for successful treatment of chronic hepatitis C virus (HCV) infections in low-income settings, as well as for therapy of difficult-to-treat HCV patients. We studied the effect of ribavirin against cell-culture adapted HCV… read more here.
Keywords: hepatitis; cell culture; ribavirin; strain dependent ... See more keywords
Use of an anti-viral drug, Ribavirin, as an anti-glioblastoma therapeutic
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2016.457
Abstract: The median survival for glioblastoma patients is ~15 months despite aggressive surgery and radio-chemotherapy approaches. Thus, developing new therapeutics is necessary to improve the treatment of these invasive brain tumors, which are known to show… read more here.
Keywords: anti viral; ribavirin; glioblastoma; treatment ... See more keywords
Targeting EIF4E signaling with ribavirin in infant acute lymphoblastic leukemia
Sign Up to like & getrecommendations! Published in 2018 at "Oncogene"
DOI: 10.1038/s41388-018-0567-7
Abstract: The poor outcomes in infant acute lymphoblastic leukemia (ALL) necessitate new treatments. Here we discover that EIF4E protein is elevated in most cases of infant ALL and test EIF4E targeting by the repurposed antiviral agent… read more here.
Keywords: ribavirin; infant acute; treatment; lymphoblastic leukemia ... See more keywords