Anticancer Activity of Reconstituted Ribonuclease S‐Decorated Artificial Viral Capsid
Sign Up to like & getrecommendations! Published in 2022 at "Chembiochem"
DOI: 10.1002/cbic.202200220
Abstract: Ribonuclease S (RNase S) is an enzyme that exhibits anticancer activity by degrading RNAs within cancer cells; however, the cellular uptake efficiency is low due to its small molecular size. Here we generated RNase S‐decorated… read more here.
Keywords: artificial viral; decorated artificial; anticancer activity; ribonuclease ... See more keywords
Circular zymogens of human ribonuclease 1
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DOI: 10.1002/pro.3686
Abstract: The endogenous production of enzymes as zymogens provides a means to control catalytic activities. Here, we describe the heterologous production of ribonuclease 1 (RNase 1), which is the most prevalent secretory ribonuclease in humans, as… read more here.
Keywords: protease; zymogens human; rnase; circular zymogens ... See more keywords
Domain swapping of the C‐terminal helix promotes the dimerization of a novel ribonuclease protein from Mycobacterium tuberculosis
Sign Up to like & getrecommendations! Published in 2023 at "Protein Science"
DOI: 10.1002/pro.4644
Abstract: Polyketide metabolism‐associated proteins in Mycobacterium tuberculosis play an essential role in the survival of the bacterium, which makes them potential drug targets for the treatment of tuberculosis (TB). The novel ribonuclease protein Rv1546 is predicted… read more here.
Keywords: mycobacterium tuberculosis; ribonuclease; domain; rv1546 ... See more keywords
Structural Basis for the RNA-Guided Ribonuclease Activity of CRISPR-Cas13d
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DOI: 10.1016/j.cell.2018.09.001
Abstract: CRISPR-Cas endonucleases directed against foreign nucleic acids mediate prokaryotic adaptive immunity and have been tailored for broad genetic engineering applications. Type VI-D CRISPR systems contain the smallest known family of single effector Cas enzymes, and… read more here.
Keywords: structural basis; rna guided; ribonuclease; rna ... See more keywords
The structural features of an ancient ribonuclease from Salmo salar reveal an intriguing case of auto-inhibition.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2021.04.041
Abstract: The superfamily of vertebrate ribonucleases, a large group of evolutionarily related proteins, continues to provide interesting structural and functional information. In particular, the crystal structure of SS-RNase-2 from Salmo salar (SS2), here presented, has revealed… read more here.
Keywords: ribonuclease; inhibition; structural features; salmo salar ... See more keywords
DNA-Encoded Library Screening To Inform Design of a Ribonuclease Targeting Chimera (RiboTAC).
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c07217
Abstract: Ribonuclease targeting chimeras (RiboTACs) induce degradation of an RNA target by facilitating an interaction between an RNA and a ribonuclease (RNase). We describe the screening of a DNA-encoded library (DEL) to identify binders of monomeric… read more here.
Keywords: ribonuclease targeting; ribonuclease; encoded library; ribotac ... See more keywords
Cryo-electron microscopy structure of an archaeal ribonuclease P holoenzyme
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DOI: 10.1038/s41467-019-10496-3
Abstract: Ribonuclease P (RNase P) is an essential ribozyme responsible for tRNA 5′ maturation. Here we report the cryo-EM structures of Methanocaldococcus jannaschii (Mja) RNase P holoenzyme alone and in complex with a tRNA substrate at… read more here.
Keywords: structure archaeal; microscopy; ribonuclease; rnase ... See more keywords
Adaptive evolutionary expansion of the ribonuclease 6 in Rodentia.
Sign Up to like & getrecommendations! Published in 2019 at "Integrative zoology"
DOI: 10.1111/1749-4877.12382
Abstract: Ribonuclease 6 (RNase6 or RNase K6) is a protein that belongs to a superfamily thought to be the sole verte-brate-specific enzyme known for a wide range of physiological functions, including digestion, cytotoxicity, angiogenesis, male reproduction… read more here.
Keywords: adaptive evolutionary; ribonuclease; expansion ribonuclease; evolutionary expansion ... See more keywords
Structural insight into precursor ribosomal RNA processing by ribonuclease MRP
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DOI: 10.1126/science.abc0149
Abstract: Adapted to the task at hand RNA-based catalysts perform fundamental tasks in cellular RNA metabolism, especially in eukaryotes, where RNAs are cut by specialized ribonucleoproteins (RNPs) as part of ribosome assembly or messenger RNA regulation… read more here.
Keywords: rnase mrp; microscopy; ribonuclease mrp; ribonuclease ... See more keywords
Human angiogenin is a potent cytotoxin in the absence of ribonuclease inhibitor.
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DOI: 10.1261/rna.065516.117
Abstract: Angiogenin (ANG) is a secretory ribonuclease that promotes the proliferation of endothelial cells, leading to angiogenesis. This function relies on its ribonucleolytic activity, which is low for simple RNA substrates. Upon entry into the cytosol,… read more here.
Keywords: potent cytotoxin; ribonuclease; angiogenin; ribonuclease inhibitor ... See more keywords
Human RNase P: overview of a ribonuclease of interrelated molecular networks and gene-targeting systems
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DOI: 10.1261/rna.079475.122
Abstract: The seminal discovery of ribonuclease P (RNase P) and its catalytic RNA by Sidney Altman has not only revolutionized our understanding of life, but also opened new fields for scientific exploration and investigation. This review… read more here.
Keywords: ribonuclease; gene targeting; rnase; molecular networks ... See more keywords