Translating from Proteins to Ribonucleic Acids for Ligand‐binding Site Detection
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Informatics"
DOI: 10.1002/minf.202200059
Abstract: Identifying druggable ligand‐binding sites on the surface of the macromolecular targets is an important process in structure‐based drug discovery. Deep‐learning models have been shown to successfully predict ligand‐binding sites of proteins. As a step toward… read more here.
Keywords: acids ligand; ligand binding; translating proteins; ribonucleic acids ... See more keywords
Target-Initiated Cascade Signal Amplification Lights up a G-Quadruplex for a Label-Free Detection of Circular Ribonucleic Acids.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c01901
Abstract: Circular ribonucleic acids (circRNAs) are a type of RNA that originates through back-splicing events from linear primary transcripts. CircRNAs display high structural resistance and tissue specificity. Accurate quantification of the circRNA expression level is of… read more here.
Keywords: label free; target initiated; ribonucleic acids; initiated cascade ... See more keywords
Top-Down Mass Spectrometry of Synthetic Single Guide Ribonucleic Acids Enabled by Facile Sample Clean-Up.
Sign Up to like & getrecommendations! Published in 2023 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c03030
Abstract: In recent years, CRISPR-Cas9 genome editing has become an important technology in biomedical research and has demonstrated tremendous therapeutic potential. With Cas9 endonuclease, the use of single guide ribonucleic acids (sgRNAs) allows for sequence-specific cutting… read more here.
Keywords: guide ribonucleic; mass spectrometry; sequence; ribonucleic acids ... See more keywords
Examining micro-ribonucleic acids as diagnostic and therapeutic prospects in autoimmune hepatitis
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Clinical Immunology"
DOI: 10.1080/1744666x.2022.2074839
Abstract: ABSTRACT Introduction: Micro-ribonucleic acids modulate the immune response by affecting the post-transcriptional expression of genes that influence the proliferation and function of activated immune cells, including regulatory T cells. Individual expressions or patterns in peripheral… read more here.
Keywords: micro ribonucleic; examining micro; autoimmune hepatitis; ribonucleic acids ... See more keywords
Long-chain noncoding ribonucleic acids affect the survival and prognosis of patients with esophageal adenocarcinoma through the autophagy pathway: construction of a prognostic model
Sign Up to like & getrecommendations! Published in 2021 at "Anti-Cancer Drugs"
DOI: 10.1097/cad.0000000000001189
Abstract: Supplemental Digital Content is available in the text. read more here.
Keywords: acids affect; ribonucleic acids; chain noncoding; affect survival ... See more keywords
Exercise responsive micro ribonucleic acids identify patients with coronary artery disease
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Preventive Cardiology"
DOI: 10.1177/2047487318808014
Abstract: Aims Exercise is a trigger for acute coronary events especially in the untrained. Identifying subjects at risk remains a challenge. We set out to assess whether a distinct pattern of micro ribonucleic acids (miRNAs) expressed… read more here.
Keywords: patients coronary; micro ribonucleic; ribonucleic acids; disease ... See more keywords
The Role of Long Noncoding Ribonucleic Acids in Glioblastoma: What the Neurosurgeon Should Know
Sign Up to like & getrecommendations! Published in 2023 at "Neurosurgery"
DOI: 10.1227/neu.0000000000002449
Abstract: A significant proportion of the human transcriptome, long noncoding RNAs (lncRNAs) play pivotal roles in several aspects of glioblastoma (GBM) pathophysiology including proliferation, invasion, radiation and temozolomide resistance, and immune modulation. The majority of lncRNAs… read more here.
Keywords: noncoding ribonucleic; long noncoding; acids glioblastoma; ribonucleic acids ... See more keywords
Molecular Mechanisms, Diagnostic Aspects and Therapeutic Opportunities of Micro Ribonucleic Acids in Atrial Fibrillation
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21082742
Abstract: Micro ribonucleic acids (miRNAs) are short non-coding RNA molecules responsible for regulation of gene expression. They are involved in many pathophysiological processes of a wide spectrum of diseases. Recent studies showed their involvement in atrial… read more here.
Keywords: atrial fibrillation; fibrillation; micro ribonucleic; ribonucleic acids ... See more keywords