Comprehensive phylogenetic analysis of the ribonucleotide reductase family reveals an ancestral clade
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DOI: 10.1101/2022.04.23.489257
Abstract: Ribonucleotide reductases (RNRs) are used by all organisms and many viruses to catalyze an essential step in the de novo biosynthesis of DNA precursors. RNRs are remarkably diverse by primary sequence and cofactor requirement, while… read more here.
Keywords: rnr family; family; comprehensive phylogenetic; ribonucleotide ... See more keywords
Evidence linking APOBEC3B genesis and evolution of innate immune antagonism by gamma-herpesvirus ribonucleotide reductases
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DOI: 10.7554/elife.83893
Abstract: Viruses have evolved diverse mechanisms to antagonize host immunity such as direct inhibition and relocalization of cellular APOBEC3B (A3B) by the ribonucleotide reductase (RNR) of Epstein-Barr virus. Here, we investigate the mechanistic conservation and evolutionary… read more here.
Keywords: world monkeys; gamma; ribonucleotide; innate immune ... See more keywords
Non-host class II ribonucleotide reductase in Thermus viruses: sequence adaptation and host interaction
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DOI: 10.7717/peerj.6700
Abstract: Ribonucleotide reductases (RNR) are essential enzymes for all known life forms. Their current taxonomic distribution suggests extensive horizontal gene transfer e.g., by processes involving viruses. To improve our understanding of the underlying processes, we characterized… read more here.
Keywords: thermus viruses; class; host; ribonucleotide ... See more keywords