A Structurally Divergent Class Ia Ribonucleotide Reductase from a Tick-Borne Pathogen.
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DOI: 10.1021/acs.biochem.5c00316
Abstract: Ribonucleotide reductases (RNRs) generate 2'-deoxynucleotides for DNA biosynthesis, a reaction essential to all life. Class I RNRs have two subunits, α and β. α binds and reduces the substrate, whereas β oxidizes one of the… read more here.
Keywords: cluster; class; ribonucleotide; pathogen ... See more keywords
Characterization of a second class Ie ribonucleotide reductase
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DOI: 10.1038/s42003-025-07565-3
Abstract: Class I ribonucleotide reductases (RNRs) convert ribonucleotides into deoxyribonucleotides under oxic conditions. The R2 subunit provides a radical required for catalysis conducted by the R1 subunit. In most R2s the radical is generated on a… read more here.
Keywords: characterization second; class ribonucleotide; class; ribonucleotide ... See more keywords
Comprehensive phylogenetic analysis of the ribonucleotide reductase family reveals an ancestral clade
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DOI: 10.1101/2022.04.23.489257
Abstract: Ribonucleotide reductases (RNRs) are used by all organisms and many viruses to catalyze an essential step in the de novo biosynthesis of DNA precursors. RNRs are remarkably diverse by primary sequence and cofactor requirement, while… read more here.
Keywords: rnr family; family; comprehensive phylogenetic; ribonucleotide ... See more keywords
NrdR in Streptococcus and Listeria spp.: DNA Helix Phase Dependence of the Bacterial Ribonucleotide Reductase Repressor
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DOI: 10.1111/mmi.15349
Abstract: NrdR is a universal transcriptional repressor of bacterial genes coding for ribonucleotide reductases (RNRs), essential enzymes that provide DNA building blocks in all living cells. Despite its bacterial prevalence, the NrdR mechanism has been scarcely… read more here.
Keywords: streptococcus; nrdr; ribonucleotide; nrdr boxes ... See more keywords
Evidence linking APOBEC3B genesis and evolution of innate immune antagonism by gamma-herpesvirus ribonucleotide reductases
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DOI: 10.7554/elife.83893
Abstract: Viruses have evolved diverse mechanisms to antagonize host immunity such as direct inhibition and relocalization of cellular APOBEC3B (A3B) by the ribonucleotide reductase (RNR) of Epstein-Barr virus. Here, we investigate the mechanistic conservation and evolutionary… read more here.
Keywords: world monkeys; gamma; ribonucleotide; innate immune ... See more keywords
Non-host class II ribonucleotide reductase in Thermus viruses: sequence adaptation and host interaction
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DOI: 10.7717/peerj.6700
Abstract: Ribonucleotide reductases (RNR) are essential enzymes for all known life forms. Their current taxonomic distribution suggests extensive horizontal gene transfer e.g., by processes involving viruses. To improve our understanding of the underlying processes, we characterized… read more here.
Keywords: thermus viruses; class; host; ribonucleotide ... See more keywords