Poly(adenosine diphosphate ribose) polymerase inhibitors induce autophagy‐mediated drug resistance in ovarian cancer cells, xenografts, and patient‐derived xenograft models
Sign Up to like & getrecommendations! Published in 2019 at "Cancer"
DOI: 10.1002/cncr.32600
Abstract: Poly(adenosine diphosphate ribose) polymerase (PARP) inhibitors exhibit promising activity against ovarian cancers, but their efficacy can be limited by acquired drug resistance. This study explores the role of autophagy in regulating the sensitivity of ovarian… read more here.
Keywords: drug resistance; adenosine diphosphate; poly adenosine; ribose polymerase ... See more keywords
SARC025 arms 1 and 2: A phase 1 study of the poly(ADP‐ribose) polymerase inhibitor niraparib with temozolomide or irinotecan in patients with advanced Ewing sarcoma
Sign Up to like & getrecommendations! Published in 2020 at "Cancer"
DOI: 10.1002/cncr.33349
Abstract: In preclinical Ewing sarcoma (ES) models, poly(adenosine diphosphate ribose) polymerase (PARP) inhibitors were identified as a potential therapeutic strategy with synergy in combination with cytotoxic agents. This study evaluated the safety and dosing of the… read more here.
Keywords: ribose polymerase; ewing sarcoma; inhibitor niraparib;
Targeting cervical cancer: Is there a role for poly (ADP‐ribose) polymerase inhibition?
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29440
Abstract: Patients with metastatic and recurrent cervical cancer (CC) have a poor prognosis with limited palliative treatment options. Increasing understanding of the cellular aberrations inherent to cancer cells has allowed the development of therapies to target… read more here.
Keywords: cancer role; poly adp; cervical cancer; ribose polymerase ... See more keywords
Development and evaluation of poly adenosine 5'-diphosphate-ribose polymerase 1 immobilization-based receptor chromatography.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of separation science"
DOI: 10.1002/jssc.202000856
Abstract: Yanghe decoction is a traditional Chinese medicine prescription and has been used for breast cancer treatment for many years. However, the effective ingredients in the decoction have not been identified. The expression of poly (ADP-ribose)… read more here.
Keywords: ribose polymerase; medicine; adp ribose; poly adp ... See more keywords
Poly (ADP-ribose) Polymerase Inhibition in Patients with Breast Cancer and BRCA 1 and 2 Mutations
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DOI: 10.1007/s40265-019-01235-5
Abstract: The poly-(ADP-ribose) polymerase (PARP) inhibitors olaparib and talazoparib, have recently been approved for use in patients with metastatic breast cancer (BC) and germline BRCA 1 or 2 mutations due to improved progression-free survival compared to… read more here.
Keywords: poly adp; brca mutations; breast cancer; ribose polymerase ... See more keywords
A DNA-encoded library for the identification of natural product binders that modulate poly (ADP-ribose) polymerase 1, a validated anti-cancer target.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.04.022
Abstract: Natural products have been an invaluable source of drug discovery, but their targets remain largely unknown. Natural products enriched DNA-encoded chemical libraries (nDELs) empower the researchers to rapidly and economically screen numerous natural products against… read more here.
Keywords: poly adp; dna; natural products; dna encoded ... See more keywords
Quartz Crystal Microbalance Detection of Poly(ADP-ribose) Polymerase-1 Based on GNRs Signal Amplification.
Sign Up to like & getrecommendations! Published in 2019 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.9b01366
Abstract: Recent findings have thrust poly (ADP-ribose) polymerase-1 (PARP-1) into the limelight as potential biomarker and chemotherapeutic target for cancer. Thus, a sensitive method for detection of PARP-1 is necessary for early diagnosis of cancer and… read more here.
Keywords: detection; poly adp; quartz crystal; ribose polymerase ... See more keywords
An 18F-Labeled Poly(ADP-ribose) Polymerase Positron Emission Tomography Imaging Agent
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DOI: 10.1021/acs.jmedchem.8b00138
Abstract: Poly(ADP-ribose) polymerase (PARP) is involved in repair of DNA breaks and is over-expressed in a wide variety of tumors, making PARP an attractive biomarker for positron emission tomography (PET) and single photon emission computed tomography… read more here.
Keywords: poly adp; ribose polymerase; parp; adp ribose ... See more keywords
Practical and Scalable Manufacturing Process for the Key Intermediate of Poly(ADP-Ribose) Polymerase Inhibitor Olaparib
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DOI: 10.1021/acsomega.1c06920.s001
Abstract: Olaparib (Lynparza) is a potent, highly selective inhibitor of poly(ADP-ribose)polymerase enzymes, approved by the U.S. FDA and EMA for the treatment of ovarian cancer. Herein, we report a practical, economical, and scalable process for the… read more here.
Keywords: poly adp; adp ribose; inhibitor; ribose polymerase ... See more keywords
Discovery of potent 2,4-difluoro-linker poly(ADP-ribose) polymerase 1 inhibitors with enhanced water solubility and in vivo anticancer efficacy
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DOI: 10.1038/aps.2017.104
Abstract: Poly (ADP-ribose) polymerase 1 (PARP1) is overexpressed in a variety of cancers, especially in breast and ovarian cancers; tumor cells that are deficient in breast cancer gene 1/2 (BRCA1/2) are highly sensitive to PARP1 inhibition.… read more here.
Keywords: ribose polymerase; adp ribose; linker; poly adp ... See more keywords
Poly (ADP-ribose) polymerase (PARP) as target for the treatment of epithelial ovarian cancer: what to know
Sign Up to like & getrecommendations! Published in 2021 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2021.1901882
Abstract: ABSTRACT Introduction Poly (ADP-ribose) polymerase (PARP) inhibitors are being developed in maintenance and recurrence treatment settings of epithelial ovarian cancers (EOCs) with BRCA 1–2 gene mutation. PARP inhibitors are the first example of drugs targeting… read more here.
Keywords: parp inhibitors; poly adp; treatment; ribose polymerase ... See more keywords