Poly(adenosine diphosphate-ribose) polymerase as therapeutic target: lessons learned from its inhibitors
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.16859
Abstract: Poly(ADP-ribose) polymerases are a family of DNA-dependent nuclear enzymes catalyzing the transfer of ADP-ribose moieties from cellular nicotinamide-adenine-dinucleotide to a variety of target proteins. Although they have been considered as resident nuclear elements of the… read more here.
Keywords: adenosine diphosphate; poly adp; target; poly adenosine ... See more keywords
Poly (ADP-ribose) polymerases as PET imaging targets for central nervous system diseases
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.1062432
Abstract: Poly (ADP-ribose) polymerases (PARPs) constitute of 17 members that are associated with divergent cellular processes and play a crucial role in DNA repair, chromatin organization, genome integrity, apoptosis, and inflammation. Multiple lines of evidence have… read more here.
Keywords: central nervous; ribose polymerases; imaging targets; poly adp ... See more keywords