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   Articles with "ribosomal frameshifting" as a keyword



A drug screening toolkit based on the –1 ribosomal frameshifting of SARS-CoV-2

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recommendations! Published in 2020 at "Heliyon"

DOI: 10.1016/j.heliyon.2020.e04793

Abstract: The –1 ribosomal frameshifting is vital for the translation of the open reading frame (ORF)1b in SARS-CoV-2. The products of ORF1b participate in viral replication. Therefore, changing the frameshift frequency reduces the survival of the… read more here.

Keywords: frameshifting sars; ribosomal frameshifting; screening toolkit; drug screening ... See more keywords

Stem loop binding protein promotes SARS-CoV-2 replication via -1 programmed ribosomal frameshifting

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recommendations! Published in 2025 at "Signal Transduction and Targeted Therapy"

DOI: 10.1038/s41392-025-02277-w

Abstract: The -1 programmed ribosomal frameshifting (-1 PRF) in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial for keeping the balance between pp1a and pp1ab polyproteins. To date, the host factors influencing this process remain… read more here.

Keywords: sars cov; stem loop; protein; ribosomal frameshifting ... See more keywords

Ribosomal frameshifting selectively modulates the assembly, function, and pharmacological rescue of a misfolded CFTR variant

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recommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2414768121

Abstract: Significance Many diseases stem from imbalances between protein synthesis and degradation that arise from mutations and/or cellular stressors. The molecular mechanisms of such lapses in proteostasis often coincide with aberrant regulation of protein translation. Here,… read more here.

Keywords: function pharmacological; assembly function; ribosomal frameshifting; modulates assembly ... See more keywords

Coordination of -1 programmed ribosomal frameshifting by transcript and nascent chain features revealed by deep mutational scanning

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recommendations! Published in 2021 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkab1172

Abstract: Abstract Programmed ribosomal frameshifting (PRF) is a translational recoding mechanism that enables the synthesis of multiple polypeptides from a single transcript. During translation of the alphavirus structural polyprotein, the efficiency of −1PRF is coordinated by… read more here.

Keywords: ribosomal frameshifting; transcript nascent; chain; mutational scanning ... See more keywords

Programmed ribosomal frameshifting during PLEKHM2 mRNA decoding generates a constitutively active proteoform that supports myocardial function

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recommendations! Published in 2025 at "Science Advances"

DOI: 10.1126/sciadv.ady1742

Abstract: Programmed ribosomal frameshifting is a process where a proportion of ribosomes change their reading frame on an mRNA. While frameshifting is commonly used by viruses, very few phylogenetically conserved examples are known in nuclear encoded… read more here.

Keywords: plekhm2; function; ribosomal frameshifting; plekhm2 mrna ... See more keywords

Abracadabra, One Becomes Two: The Importance of Context in Viral −1 Programmed Ribosomal Frameshifting

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recommendations! Published in 2022 at "mBio"

DOI: 10.1128/mbio.02468-21

Abstract: The constrained nature of viral genomes has allowed a translational sleight of hand known as −1 Programmed Ribosomal Frameshifting (−1 PRF) to flourish. Numerous studies have sought to tease apart the mechanisms and implications of… read more here.

Keywords: programmed ribosomal; ribosomal frameshifting; prf; abracadabra one ... See more keywords

Evolutionary origin of the frameshift sites in the ribosomal frameshifting genes of Euplotes

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recommendations! Published in 2025 at "BMC Genomics"

DOI: 10.1186/s12864-025-11870-w

Abstract: Programmed ribosome frameshifting is a translational recoding event in which ribosomes slip forward or backward along the mRNA. Although genes utilizing programmed ribosomal frameshifting for their expression have been found in most organisms, such genes… read more here.

Keywords: indel sites; evolutionary origin; frameshift sites; ribosomal frameshifting ... See more keywords

Thinking Outside the Frame: Impacting Genomes Capacity by Programmed Ribosomal Frameshifting

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recommendations! Published in 2022 at "Frontiers in Molecular Biosciences"

DOI: 10.3389/fmolb.2022.842261

Abstract: Translation facilitates the transfer of the genetic information stored in the genome via messenger RNAs to a functional protein and is therefore one of the most fundamental cellular processes. Programmed ribosomal frameshifting is a ubiquitous… read more here.

Keywords: programmed ribosomal; outside frame; ribosomal frameshifting; frame impacting ... See more keywords