A drug screening toolkit based on the –1 ribosomal frameshifting of SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2020 at "Heliyon"
DOI: 10.1016/j.heliyon.2020.e04793
Abstract: The –1 ribosomal frameshifting is vital for the translation of the open reading frame (ORF)1b in SARS-CoV-2. The products of ORF1b participate in viral replication. Therefore, changing the frameshift frequency reduces the survival of the… read more here.
Keywords: frameshifting sars; ribosomal frameshifting; screening toolkit; drug screening ... See more keywords
Coordination of -1 programmed ribosomal frameshifting by transcript and nascent chain features revealed by deep mutational scanning
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DOI: 10.1093/nar/gkab1172
Abstract: Abstract Programmed ribosomal frameshifting (PRF) is a translational recoding mechanism that enables the synthesis of multiple polypeptides from a single transcript. During translation of the alphavirus structural polyprotein, the efficiency of −1PRF is coordinated by… read more here.
Keywords: ribosomal frameshifting; transcript nascent; chain; mutational scanning ... See more keywords
Abracadabra, One Becomes Two: The Importance of Context in Viral −1 Programmed Ribosomal Frameshifting
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DOI: 10.1128/mbio.02468-21
Abstract: The constrained nature of viral genomes has allowed a translational sleight of hand known as −1 Programmed Ribosomal Frameshifting (−1 PRF) to flourish. Numerous studies have sought to tease apart the mechanisms and implications of… read more here.
Keywords: programmed ribosomal; ribosomal frameshifting; prf; abracadabra one ... See more keywords
Thinking Outside the Frame: Impacting Genomes Capacity by Programmed Ribosomal Frameshifting
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DOI: 10.3389/fmolb.2022.842261
Abstract: Translation facilitates the transfer of the genetic information stored in the genome via messenger RNAs to a functional protein and is therefore one of the most fundamental cellular processes. Programmed ribosomal frameshifting is a ubiquitous… read more here.
Keywords: programmed ribosomal; outside frame; ribosomal frameshifting; frame impacting ... See more keywords