Mild cognitive impairment is associated with low copy number of ribosomal genes in the genomes of elderly people
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DOI: 10.3389/fgene.2022.967448
Abstract: Introduction: Mild cognitive impairments (MCI) accompanying aging are associated with oxidative stress. The ability of cells to respond to stress is determined by the protein synthesis level, which depends on the ribosomes number. Ribosomal deficit… read more here.
Keywords: associated low; mild cognitive; elderly people; number ... See more keywords
Effects of Psychotropic Drugs on Ribosomal Genes and Protein Synthesis
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DOI: 10.3390/ijms23137180
Abstract: Altered protein synthesis has been implicated in the pathophysiology of several neuropsychiatric disorders, particularly schizophrenia. Ribosomes are the machinery responsible for protein synthesis. However, there remains little information on whether current psychotropic drugs affect ribosomes… read more here.
Keywords: effects psychotropic; synthesis; ribosomal genes; psychotropic drugs ... See more keywords
Variability of Human rDNA and Transcription Activity of the Ribosomal Genes
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DOI: 10.3390/ijms232315195
Abstract: Human ribosomal DNA is represented by hundreds of repeats in each cell. Every repeat consists of two parts: a 13 kb long 47S DNA with genes encoding 18S, 5.8S, and 28S RNAs of ribosomal particles,… read more here.
Keywords: dna; transcription; ribosomal genes; human rdna ... See more keywords