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Published in 2019 at "Current topics in microbiology and immunology"
DOI: 10.1007/82_2018_133
Abstract: Non-ribosomal peptide (NRP) natural products are one of the most promising resources for drug discovery and development because of their wide-ranging of therapeutic potential, and their behavior as virulence factors and signaling molecules. The NRPs…
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Keywords:
ribosomal peptide;
based protein;
nrps machinery;
activity based ... See more keywords
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Published in 2017 at "ACS chemical biology"
DOI: 10.1021/acschembio.7b00081
Abstract: The β-hydroxylation of l-histidine is the first step in the biosynthesis of the imidazolone base of the antifungal drug nikkomycin. The cytochrome P450 (NikQ) hydroxylates the amino acid while it is appended via a phosphopantetheine…
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Keywords:
biosynthesis;
ribosomal peptide;
amino acid;
peptide synthetase ... See more keywords
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2
Published in 2022 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.2c00565
Abstract: Recombination of biosynthetic gene clusters including those of non-ribosomal peptide synthetases (NRPSs) is essential for understanding the mechanisms of biosynthesis. Due to relatively huge gene cluster sizes ranging from 10 to 150 kb, the prevalence…
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Keywords:
gene assembly;
seam ogab;
non ribosomal;
ribosomal peptide ... See more keywords
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Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c11082
Abstract: Macrocyclization improves the pharmaceutical properties of peptides; however, regio- and chemoselective intramolecular cyclizations remain challenging. Here we developed a streamlined chemoenzymatic approach to synthesize cyclic peptides by exploiting non-ribosomal peptide (NRP) cyclases. Linear peptides linked…
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Keywords:
cyclic peptides;
non ribosomal;
ribosomal peptide;
chemoenzymatic synthesis ... See more keywords
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Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-021-27512-0
Abstract: Non-Ribosomal Peptide Synthetases (NRPSs) assemble a diverse range of natural products with important applications in both medicine and agriculture. They consist of several multienzyme subunits that must interact with each other in a highly controlled…
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Keywords:
chain;
domain;
non ribosomal;
type thioesterase ... See more keywords
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Published in 2020 at "Nature Catalysis"
DOI: 10.1038/s41929-020-0456-7
Abstract: Heterochiral coupling is favoured in abiotic peptide bond formation, whereas biotic peptide bond formation is dominated by homochiral coupling. Here, we report that heterochiral coupling is a rather general paradigm in the head-to-tail macrolactamization of…
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Keywords:
macrolactamization;
ribosomal peptide;
non ribosomal;
heterochiral coupling ... See more keywords
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Published in 2020 at "Chemical Science"
DOI: 10.1039/d0sc03483e
Abstract: Non-ribosomal peptide synthesis is an important biosynthesis pathway in secondary metabolism. In this study we have investigated modularisation and redesign strategies for the glycopeptide antibiotic teicoplanin. Using the relocation or exchange of domains within the…
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Keywords:
ribosomal peptide;
strategies redesign;
non ribosomal;
modular reengineering ... See more keywords
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1
Published in 2022 at "Environmental microbiology reports"
DOI: 10.1111/1758-2229.13118
Abstract: Photorhabdus, the symbiotic bacteria of Heterorhabditis nematodes, has been reported to possess many non-ribosomal peptide synthetase (NRPS) biosynthesis gene clusters (BGCs). To provide an in-depth assessment of the non-ribosomal peptide biosynthetic potential of Photorhabdus, we…
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Keywords:
biosynthetic potential;
photorhabdus;
non ribosomal;
ribosomal peptide ... See more keywords
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Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0270359
Abstract: The growing demand for natural pigments in the industrial sector is a significant driving force in the development of production processes. The production of natural blue pigments, which have wide industrial applications, using microbial systems…
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Keywords:
platform;
antioxidant activity;
non ribosomal;
ribosomal peptide ... See more keywords