Inhaled mRNA Nanoformulation with Biogenic Ribosomal Protein Reverses Established Pulmonary Fibrosis in a BleomycinâInduced Murine Model
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202107506
Abstract: Idiopathic pulmonary fibrosis (IPF), a lethal respiratory disease with few treatment options, occurs due to repetitive microinjuries to alveolar epithelial cells (AECs) and progresses with an overwhelming deposition of extracellular matrix (ECM), ultimately resulting in… read more here.
Keywords: ribosomal protein; bleomycin induced; pulmonary fibrosis; mrna nanoformulation ... See more keywords
Exploitation of the ribosomal protein L10 R98S mutation to enhance recombinant protein production in mammalian cells
Sign Up to like & getrecommendations! Published in 2022 at "Engineering in Life Sciences"
DOI: 10.1002/elsc.202100124
Abstract: Mammalian cells are commonly used to produce recombinant protein therapeutics, but suffer from a high cost per mg of protein produced. There is therefore great interest in improving protein yields to reduce production cost. We… read more here.
Keywords: ribosomal protein; protein production; rpl10 r98s; production ... See more keywords
Circular Permutation Obscures Universality of a Ribosomal Protein
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Evolution"
DOI: 10.1007/s00239-018-9869-1
Abstract: Functions, origins, and evolution of the translation system are best understood in the context of unambiguous and phylogenetically based taxonomy and nomenclature. Here, we map ribosomal proteins onto the tree of life and provide a… read more here.
Keywords: protein; ribosomal proteins; permutation obscures; circular permutation ... See more keywords
Chemical shift assignments of Ribosomal protein S1 from Mycobacterium tuberculosis
Sign Up to like & getrecommendations! Published in 2017 at "Biomolecular NMR Assignments"
DOI: 10.1007/s12104-017-9734-y
Abstract: RpsA, also known as ribosomal protein S1, is an essential protein required for translation initiation of mRNAs when their Shine-Dalgarno sequence is degenerated (Sorensen et al. 1998). In addition, RpsA of Mycobacterium tuberculosis (M. tb)… read more here.
Keywords: chemical shift; shift assignments; rpsa; ribosomal protein ... See more keywords
Impaired Plastid Ribosomal Protein L3 Causes Albino Seedling Lethal Phenotype in Rice
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Plant Biology"
DOI: 10.1007/s12374-019-0380-z
Abstract: The chloroplast is a semiautonomous photosynthetic organelle that is essential for plant growth and development, particularly in crops via manipulation of its photosynthetic capacity and the biosynthesis of carbon skeletons. Plastid ribosomal proteins (PRPs) are… read more here.
Keywords: plastid ribosomal; impaired plastid; rice; ribosomal protein ... See more keywords
PSMD9 ribosomal protein network maintains nucleolar architecture and WT p53 levels.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.05.004
Abstract: Capitalizing on an unexpected observation that multiple free ribosomal proteins co-purify/pull-down with PSMD9, we report here for the first time that PSMD9 is necessary to maintain the morphology and integrity of the nucleolus. As seen… read more here.
Keywords: p53; psmd9 ribosomal; ribosomal proteins; ribosomal protein ... See more keywords
Oligoglutamylation of E. coli ribosomal protein S6 is under growth phase control.
Sign Up to like & getrecommendations! Published in 2019 at "Biochimie"
DOI: 10.1016/j.biochi.2019.09.008
Abstract: Ribosomal protein S6 in Escherichia coli is modified by ATP-dependent glutamate ligase RimK. Up to four glutamate residues are added to the C-terminus of S6 protein. In this work we demonstrated that unlike the majority… read more here.
Keywords: protein; phase; oligoglutamylation coli; ribosomal protein ... See more keywords
Alterations in the ribosomal protein bL12 of E. coli affecting the initiation, elongation and termination of protein synthesis.
Sign Up to like & getrecommendations! Published in 2020 at "Biochimie"
DOI: 10.1016/j.biochi.2020.06.006
Abstract: In bacteria, ribosomal protein bL12 forms the prominent stalk structure on the ribosome and binds to multiple, distinct translational GTPase factors during the sequential steps of translation. Using a genetic selection in E. coli for… read more here.
Keywords: protein; bl12; protein bl12; coli ... See more keywords
Knockdown of the mRNA encoding the ribosomal protein eL38 in mammalian cells causes a substantial reorganization of genomic transcription.
Sign Up to like & getrecommendations! Published in 2021 at "Biochimie"
DOI: 10.1016/j.biochi.2021.02.017
Abstract: The ribosomal protein eL38 is a component of the mammalian translation machine. The deletion of the Rpl38 locus in mice results in the Tail-short (Ts) mutant phenotype characterized by a shortened tail and other defects… read more here.
Keywords: transcription; protein el38; genomic transcription; reorganization genomic ... See more keywords
Lead compounds and key residues of ribosomal protein S1 in drug-resistant Mycobacterium tuberculosis.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.09.024
Abstract: Ribosomal protein S1 (RpsA) has been identified as a novel target of pyrazinoic acid (POA), which is the active form of pyrazinamide (PZA), in vivo. RpsA plays a crucial role in trans-translation, which is widespread… read more here.
Keywords: resistant mycobacterium; drug; drug resistant; tuberculosis ... See more keywords
Suppression of ribosomal protein RPS6KB1 by Nexrutine increases sensitivity of prostate tumors to radiation.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.07.009
Abstract: Radiation therapy (XRT) is a standard treatment for prostate cancer (PCa). Although dose escalation increases local control, toxicity hampers further escalation. Broader improvement will be possible by the addition of adjuvant therapies, which can synergize… read more here.
Keywords: sensitivity; pca; ribosomal protein; suppression ribosomal ... See more keywords