Hold on to your friends: Dedicated chaperones of ribosomal proteins
Sign Up to like & getrecommendations! Published in 2017 at "BioEssays"
DOI: 10.1002/bies.201600153
Abstract: Eukaryotic ribosomes are assembled from their components, the ribosomal RNAs and ribosomal proteins, in a tremendously complex, multi‐step process, which primarily takes place in the nuclear compartment. Therefore, most ribosomal proteins have to travel from… read more here.
Keywords: dedicated chaperones; ribosomal proteins; friends dedicated; chaperones ribosomal ... See more keywords
The roles of moonlight ribosomal proteins in the development of human cancers
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27722
Abstract: “Moonlighting protein” is a term used to define a single protein with multiple functions and different activities that are not derived from gene fusions, multiple RNA splicing, or the proteolytic activity of promiscuous enzymes. Different… read more here.
Keywords: proteins development; human cancers; ribosomal proteins; roles moonlight ... See more keywords
Fatal attraction: The roles of ribosomal proteins in the viral life cycle
Sign Up to like & getrecommendations! Published in 2020 at "Wiley Interdisciplinary Reviews: RNA"
DOI: 10.1002/wrna.1613
Abstract: Upon viral infection of a host cell, each virus starts a program to generate many progeny viruses. Although viruses interact with the host cell in numerous ways, one critical step in the virus life cycle… read more here.
Keywords: ribosomal proteins; life cycle; infection; proteins viral ... See more keywords
Circular Permutation Obscures Universality of a Ribosomal Protein
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Evolution"
DOI: 10.1007/s00239-018-9869-1
Abstract: Functions, origins, and evolution of the translation system are best understood in the context of unambiguous and phylogenetically based taxonomy and nomenclature. Here, we map ribosomal proteins onto the tree of life and provide a… read more here.
Keywords: protein; ribosomal proteins; permutation obscures; circular permutation ... See more keywords
PSMD9 ribosomal protein network maintains nucleolar architecture and WT p53 levels.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.05.004
Abstract: Capitalizing on an unexpected observation that multiple free ribosomal proteins co-purify/pull-down with PSMD9, we report here for the first time that PSMD9 is necessary to maintain the morphology and integrity of the nucleolus. As seen… read more here.
Keywords: p53; psmd9 ribosomal; ribosomal proteins; ribosomal protein ... See more keywords
On-Site Ribosome Remodeling by Locally Synthesized Ribosomal Proteins in Axons
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DOI: 10.1016/j.celrep.2019.11.025
Abstract: Summary Ribosome assembly occurs mainly in the nucleolus, yet recent studies have revealed robust enrichment and translation of mRNAs encoding many ribosomal proteins (RPs) in axons, far away from neuronal cell bodies. Here, we report… read more here.
Keywords: locally synthesized; ribosomal proteins; ribosome remodeling; translation ... See more keywords
Ribosomal proteins as a possible tool for blocking SARS-COV 2 virus replication for a potential prospective treatment
Sign Up to like & getrecommendations! Published in 2020 at "Medical Hypotheses"
DOI: 10.1016/j.mehy.2020.109904
Abstract: Coronavirus disease (COVID-19) is caused by SARS-COV2 and has resulted in more than four million cases globally and the death cases exceeded 300,000. Normally, a range of surviving and propagating host factors must be employed… read more here.
Keywords: ribosomal proteins; proteins possible; possible tool; replication ... See more keywords
Ribosomal Proteins Regulate MHC Class I Peptide Generation for Immunosurveillance.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular cell"
DOI: 10.1016/j.molcel.2018.12.020
Abstract: The MHC class I antigen presentation system enables T cell immunosurveillance of cancers and viruses. A substantial fraction of the immunopeptidome derives from rapidly degraded nascent polypeptides (DRiPs). By knocking down each of the 80 ribosomal… read more here.
Keywords: immunosurveillance; peptide generation; mhc class; ribosomal proteins ... See more keywords
Ribosomal proteins: insight into molecular roles and functions in hepatocellular carcinoma
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DOI: 10.1038/onc.2017.343
Abstract: Ribosomes, which are important sites for the synthesis of proteins related to expression and transmission of genetic information in humans, have a complex structure and diverse functions. They consist of a variety of ribosomal proteins… read more here.
Keywords: hepatocellular carcinoma; ribosomal proteins; molecular roles; proteins insight ... See more keywords
Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy
Sign Up to like & getrecommendations! Published in 2021 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-021-00728-8
Abstract: Ribosome biogenesis and protein synthesis are fundamental rate-limiting steps for cell growth and proliferation. The ribosomal proteins (RPs), comprising the structural parts of the ribosome, are essential for ribosome assembly and function. In addition to… read more here.
Keywords: ribosomal proteins; ribosomal defects; targeted therapy; cancer ... See more keywords
MicroRNA-7641 is a regulator of ribosomal proteins and a promising targeting factor to improve the efficacy of cancer therapy
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-08737-w
Abstract: Many diseases, including myocardial infarction, autoimmune disease, viral diseases, neurodegenerative diseases, and cancers, are frequently diagnosed with aberrant expression of microRNAs (miRNAs) and their allied pathways. This indicates the crucial role of miRNAs in maintaining… read more here.
Keywords: ribosomal proteins; mir 7641; expression; cancer cells ... See more keywords