Orchestrating ribosomal RNA folding during ribosome assembly
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202200066
Abstract: Construction of the eukaryotic ribosome is a complex process in which a nascent ribosomal RNA (rRNA) emerging from RNA Polymerase I hierarchically folds into a native three‐dimensional structure. Modular assembly of individual RNA domains through… read more here.
Keywords: folding ribosome; ribosomal rna; rna folding; rna ... See more keywords
Cloning and characterisation of a ribosomal RNA gene repeat unit from groundnut
Sign Up to like & getrecommendations! Published in 2019 at "Plant Cell Reports"
DOI: 10.1007/s002990000309
Abstract: Abstract. Characterisation of a ribosomal RNA gene repeat unit (rDNA) was carried out on groundnut, Arachis hypogaea L. The rDNA was cloned, a restriction map constructed and the 5.8S and internal transcribed spacer (ITS1 and… read more here.
Keywords: ribosomal rna; gene repeat; characterisation ribosomal; rna gene ... See more keywords
FMRP Interacts with C/D Box snoRNA in the Nucleus and Regulates Ribosomal RNA Methylation
Sign Up to like & getrecommendations! Published in 2018 at "iScience"
DOI: 10.1016/j.isci.2018.11.007
Abstract: Summary FMRP is an RNA-binding protein that is known to localize in the cytoplasm and in the nucleus. Here, we have identified an interaction of FMRP with a specific set of C/D box snoRNAs in… read more here.
Keywords: fmrp interacts; methylation; nucleus; ribosomal rna ... See more keywords
Abundance of ribosomal RNA gene copies in the genomes of schizophrenia patients
Sign Up to like & getrecommendations! Published in 2018 at "Schizophrenia Research"
DOI: 10.1016/j.schres.2018.01.001
Abstract: OBJECTIVE The ribosome is a critical component of the translation machinery. The key component of ribosomes is ribosomal RNA (rRNA). Dysregulation of rRNA biogenesis has been implicated in some human diseases. One of the factors… read more here.
Keywords: abundance ribosomal; copy number; ribosomal rna; gene copies ... See more keywords
First-In-Class Inhibitor of Ribosomal RNA Synthesis with Antimicrobial Activity against Staphylococcus aureus.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemistry"
DOI: 10.1021/acs.biochem.7b00349
Abstract: We report the discovery of the first bacterial ribosomal RNA (rRNA) synthesis inhibitor that has specific antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA). A pharmacophore model was constructed on the basis of the protein-protein interaction… read more here.
Keywords: staphylococcus aureus; ribosomal rna; antimicrobial activity; synthesis ... See more keywords
Dual-mode Detection of Bacterial 16S Ribosomal RNA in Tissues.
Sign Up to like & getrecommendations! Published in 2020 at "ACS sensors"
DOI: 10.1021/acssensors.0c00252
Abstract: The specific detection of pathogens has long been recognized as a vital strategy for controlling bacterial infections. Herein, a novel hydrophilic aromatic-imide-based thermally activated delayed fluorescence (TADF) probe, AI-Cz-Neo, is designed and synthesized by conjugation… read more here.
Keywords: bacterial 16s; dual mode; detection; ribosomal rna ... See more keywords
Structural and evolutionary insights into ribosomal RNA methylation.
Sign Up to like & getrecommendations! Published in 2018 at "Nature chemical biology"
DOI: 10.1038/nchembio.2569
Abstract: Methylation of nucleotides in ribosomal RNAs (rRNAs) is a ubiquitous feature that occurs in all living organisms. Identification of all enzymes responsible for rRNA methylation, as well as mapping of all modified rRNA residues, is… read more here.
Keywords: rna methylation; methylation; ribosomal rna; evolutionary insights ... See more keywords
Rapid identification and phylogenetic classification of diverse bacterial pathogens in a multiplexed hybridization assay targeting ribosomal RNA
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-40792-3
Abstract: Rapid bacterial identification remains a critical challenge in infectious disease diagnostics. We developed a novel molecular approach to detect and identify a wide diversity of bacterial pathogens in a single, simple assay, exploiting the conservation,… read more here.
Keywords: identification; hybridization assay; ribosomal rna; bacterial pathogens ... See more keywords
DDX39B promotes translation through regulation of pre-ribosomal RNA levels
Sign Up to like & getrecommendations! Published in 2018 at "RNA Biology"
DOI: 10.1080/15476286.2018.1517011
Abstract: ABSTRACT DDX39B, a DExD RNA helicase, is known to be involved in various cellular processes such as mRNA export, splicing and translation. Previous studies showed that the overexpression of DDX39B promotes the global translation but… read more here.
Keywords: ribosomal rna; ddx39b; pre ribosomal; ddx39b promotes ... See more keywords
Supersized Ribosomal RNA Expansion Segments in Asgard Archaea
Sign Up to like & getrecommendations! Published in 2020 at "Genome Biology and Evolution"
DOI: 10.1093/gbe/evaa170
Abstract: Abstract The ribosome’s common core, comprised of ribosomal RNA (rRNA) and universal ribosomal proteins, connects all life back to a common ancestor and serves as a window to relationships among organisms. The rRNA of the… read more here.
Keywords: common core; ribosomal rna; expansion segments; supersized ribosomal ... See more keywords
AXIOME3: Automation, eXtension, and Integration Of Microbial Ecology
Sign Up to like & getrecommendations! Published in 2021 at "GigaScience"
DOI: 10.1093/gigascience/giab006
Abstract: Abstract Background Advances in high-throughput sequencing accessibility have democratized small subunit ribosomal RNA gene sequence data collection, coincident with an increasing availability of computational tools for sequence data processing, multivariate statistics, and data visualization. However,… read more here.
Keywords: ribosomal rna; analysis; ecology; small subunit ... See more keywords