Leucine 232 and hydrophobic residues at the ribosomal P stalk binding site are critical for biological activity of ricin
Sign Up to like & getrecommendations! Published in 2019 at "Bioscience Reports"
DOI: 10.1042/bsr20192022
Abstract: Abstract Ricin interacts with the ribosomal P stalk to cleave a conserved adenine from the α-sarcin/ricin loop (SRL) of the rRNA. Ricin toxin A chain (RTA) uses Arg235 as the most critical arginine for binding… read more here.
Keywords: stalk; activity; ribosomal stalk; rta ... See more keywords
Activation of GCN2 by the ribosomal P-stalk
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1813352116
Abstract: Significance General control nonderepressible 2 (GCN2) phosphorylates eIF2α, regulating translation in response to nutritional stress. Here, we show that although tRNA stimulates purified, recombinant human GCN2 in vitro, mammalian ribosomes are even more potent GCN2… read more here.
Keywords: ribosomal stalk; gcn2; gcn2 activation; stalk ... See more keywords
Direct visualization of translational GTPase factor pool formed around the archaeal ribosomal P-stalk by high-speed AFM
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2018975117
Abstract: Significance Translation of genetic information by the ribosome is a core biological process in all organisms. The ribosomal stalk is a multimeric ribosomal protein complex which plays an essential role in translation elongation. However, the… read more here.
Keywords: ribosomal stalk; direct visualization; archaeal ribosomal; stalk ... See more keywords
Transcriptomic profile of cystic fibrosis patients identifies type I interferon response and ribosomal stalk proteins as potential modifiers of disease severity
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DOI: 10.1371/journal.pone.0183526
Abstract: Cystic Fibrosis (CF) is the most common monogenic disease among people of Western European descent and caused by mutations in the CFTR gene. However, the disease severity is immensely variable even among patients with similar… read more here.
Keywords: ribosomal stalk; cystic fibrosis; type interferon; interferon response ... See more keywords
Mutational Analyses of the Cysteine-Rich Domain of Yvh1, a Protein Required for Translational Competency in Yeast
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DOI: 10.3390/biology11081246
Abstract: Simple Summary Ribosome maturation in eukaryotes is a highly energy-consuming, evolutionarily conserved process, directed by a large number of auxiliary proteins (>200) called trans-acting factors (TAFs). TAFs direct the ordered and directional assembly of immature… read more here.
Keywords: yvh1; 60s complexes; pre 60s; domain ... See more keywords