ELAC1 Repairs tRNAs Cleaved during Ribosome-Associated Quality Control.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.01.082
Abstract: Ribosome-associated quality control (RQC) disassembles aberrantly stalled translation complexes to recycle or degrade the constituent parts. A key step of RQC is the cleavage of P-site tRNA by the endonuclease ANKZF1 (Vms1 in yeast) to… read more here.
Keywords: associated quality; quality control; elac1 repairs; ribosome associated ... See more keywords
Ribosome-associated quality-control mechanisms from bacteria to humans.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular cell"
DOI: 10.1016/j.molcel.2022.03.038
Abstract: Ribosome-associated quality-control (RQC) surveys incomplete nascent polypeptides produced by interrupted translation. Central players in RQC are the human ribosome- and tRNA-binding protein, NEMF, and its orthologs, yeast Rqc2 and bacterial RqcH, which sense large ribosomal… read more here.
Keywords: associated quality; quality control; nascent chain; ribosome associated ... See more keywords
Molecular simulations of the ribosome and associated translation factors.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in structural biology"
DOI: 10.1016/j.sbi.2017.11.003
Abstract: The ribosome is a macromolecular complex which is responsible for protein synthesis in all living cells according to their transcribed genetic information. Using X-ray crystallography and, more recently, cryo-electron microscopy (cryo-EM), the structure of the… read more here.
Keywords: information; molecular simulations; simulations ribosome; translation factors ... See more keywords
Arsenite Binds to ZNF598 to Perturb Ribosome-Associated Protein Quality Control.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.9b00412
Abstract: Arsenic pollution in drinking water is a widespread public health problem, and it affects approximately 200 million people in over 70 countries. Many human diseases, including neurodegenerative disorders, are engendered by the malfunction of proteins… read more here.
Keywords: associated protein; protein quality; quality control; ribosome associated ... See more keywords
Is bRaQCing bad? New roles for ribosome associated quality control factors in stress granule regulation.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Society transactions"
DOI: 10.1042/bst20220549
Abstract: Maintenance of proteostasis is of utmost importance to cellular viability and relies on the coordination of many post-transcriptional processes to respond to stressful stimuli. Stress granules (SGs) are RNA-protein condensates that form after translation initiation… read more here.
Keywords: rqc pathway; stress; quality control; associated quality ... See more keywords
Ribosomal Stalling During Translation: Providing Substrates for Ribosome-Associated Protein Quality Control.
Sign Up to like & getrecommendations! Published in 2017 at "Annual review of cell and developmental biology"
DOI: 10.1146/annurev-cellbio-111315-125249
Abstract: Cells of all organisms survey problems during translation elongation, which may happen as a consequence of mRNA aberrations, inefficient decoding, or other sources. In eukaryotes, ribosome-associated quality control (RQC) senses elongation-stalled ribosomes and promotes dissociation… read more here.
Keywords: quality control; translation; ribosomal stalling; ribosome associated ... See more keywords
Ribosome-associated quality control of membrane proteins at the endoplasmic reticulum
Sign Up to like & getrecommendations! Published in 2020 at "Journal of cell science"
DOI: 10.1242/jcs.251983
Abstract: ABSTRACT Protein synthesis is an energetically costly, complex and risky process. Aberrant protein biogenesis can result in cellular toxicity and disease, with membrane-embedded proteins being particularly challenging for the cell. In order to protect the… read more here.
Keywords: quality control; quality; membrane proteins; ribosome associated ... See more keywords