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   Articles with "ribosome biogenesis" as a keyword



Ribosome biogenesis‐based predictive biomarkers in endocrine therapy (Anastrozole) combined with mTOR inhibitor (Vistusertib) in endometrial cancer: translational study from the VICTORIA trial in collaboration with the GINECO group

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recommendations! Published in 2022 at "Molecular Oncology"

DOI: 10.1002/1878-0261.13340

Abstract: Resistance of advanced hormone‐dependent endometrial carcinoma to endocrine therapy remains a worldwide clinical issue. We recently reported that the combination of Vistusertib (V, mTOR inhibitor) and Anastrozole (A, aromatase inhibitor) improves the progression‐free rate compared… read more here.

Keywords: ribosome biogenesis; mtor inhibitor; inhibitor; endocrine therapy ... See more keywords

HMGB proteins involved in TOR signaling as general regulators of cell growth by controlling ribosome biogenesis

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recommendations! Published in 2018 at "Current Genetics"

DOI: 10.1007/s00294-018-0842-8

Abstract: The number of ribosomes and their activity need to be highly regulated because their function is crucial for the cell. Ribosome biogenesis is necessary for cell growth and proliferation in accordance with nutrient availability and… read more here.

Keywords: ribosome biogenesis; cell growth; tor; hmgb proteins ... See more keywords

Temporal changes in the markers of ribosome biogenesis in rat soleus muscle under simulated microgravity

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recommendations! Published in 2021 at "Acta Astronautica"

DOI: 10.1016/j.actaastro.2021.05.036

Abstract: Abstract Skeletal muscle inactivity due to real or simulated microgravity results in a significant atrophy of muscle fibers. One of the key causes of disuse atrophy is a decrease in the rate of muscle protein… read more here.

Keywords: muscle; temporal changes; ribosome biogenesis; simulated microgravity ... See more keywords
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Combined RNA-Seq with small RNA revealed ribosome biogenesis and oxidative stress associated with cadmium response in carp (Cyprinus carpio L.) Hepato-pancreas

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recommendations! Published in 2020 at "Aquaculture"

DOI: 10.1016/j.aquaculture.2019.734817

Abstract: Abstract Cadmium (Cd) is one of the serious metal pollutants especially for freshwater. The carp fish can live and survive in extremely toxic conditions, providing us a useful model for studying Cd response and regulation.… read more here.

Keywords: response; hepato pancreas; stress; expression ... See more keywords

Nop-7-associated 2 (NSA2) is required for ribosome biogenesis and protein synthesis.

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recommendations! Published in 2018 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2018.09.041

Abstract: Ribosome biogenesis is a fundamental cellular process and occurs mainly in the nucleolus in eukaryotes. The process is exceptionally complex and highly regulated by numerous ribosomal and non-ribosomal factors. A recent discovery strengthened the link… read more here.

Keywords: associated nsa2; nop associated; ribosome biogenesis; synthesis ... See more keywords

Diverse Regulators of Human Ribosome Biogenesis Discovered by Changes in Nucleolar Number

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recommendations! Published in 2018 at "Cell reports"

DOI: 10.1016/j.celrep.2018.01.056

Abstract: SUMMARY Ribosome biogenesis is a highly regulated, essential cellular process. Although studies in yeast have established some of the biological principles of ribosome biogenesis, many of the intricacies of its regulation in higher eukaryotes remain… read more here.

Keywords: nucleolar number; ribosome biogenesis; diverse regulators; regulators human ... See more keywords

Noc4L-Mediated Ribosome Biogenesis Controls Activation of Regulatory and Conventional T Cells.

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recommendations! Published in 2019 at "Cell reports"

DOI: 10.1016/j.celrep.2019.03.083

Abstract: Regulatory T cell (Treg) activation is crucial for maintaining self-tolerance, but the translational regulation of this process is still poorly understood. Although ribosome biogenesis is considered a housekeeping process, emerging evidence supports the hypothesis that ribosome… read more here.

Keywords: biogenesis controls; biogenesis; noc4l mediated; ribosome biogenesis ... See more keywords

Cannabidiol modulates hippocampal genes involved in mitochondrial function, ribosome biogenesis, synapse organization, and chromatin modifications

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recommendations! Published in 2024 at "Acta Neuropsychiatrica"

DOI: 10.1017/neu.2024.13

Abstract: Abstract Background: Cannabidiol (CBD) is one of the main cannabinoids present in Cannabis sativa female flowers. Previous investigation has already provided insights into the CBD molecular mechanism; however, there is no transcriptome data for CBD… read more here.

Keywords: synapse organization; cbd administration; ribosome biogenesis; chromatin modifications ... See more keywords
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CBFβ-SMMHC regulates ribosomal gene transcription and alters ribosome biogenesis

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recommendations! Published in 2017 at "Leukemia"

DOI: 10.1038/leu.2017.53

Abstract: The core-binding factor (CBF) complex is a heterodimeric transcription factor comprising a CBFβ subunit and a variable DNA-binding RUNX subunit, usually RUNX1 in hematopoietic cells. Aside from its critical hematopoietic functions, CBF regulates the expression… read more here.

Keywords: transcription; cbf smmhc; cbf; smmhc regulates ... See more keywords

Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy

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recommendations! Published in 2021 at "Signal Transduction and Targeted Therapy"

DOI: 10.1038/s41392-021-00728-8

Abstract: Ribosome biogenesis and protein synthesis are fundamental rate-limiting steps for cell growth and proliferation. The ribosomal proteins (RPs), comprising the structural parts of the ribosome, are essential for ribosome assembly and function. In addition to… read more here.

Keywords: ribosomal proteins; ribosomal defects; targeted therapy; cancer ... See more keywords

Targeting ribosomes reprograms the tumour microenvironment and augments cancer immunotherapy

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recommendations! Published in 2025 at "British Journal of Cancer"

DOI: 10.1038/s41416-025-03109-y

Abstract: Hyperactive ribosome biogenesis is a hallmark of tumours. Current ribosome-related studies are concentrated on cancer cells. Ribosomes can regulate both tumour and non-cancer cells within the tumour microenvironment, yet the immunomodulatory effects of cellular ribosome… read more here.

Keywords: cancer; tumour microenvironment; immunotherapy; ribosome biogenesis ... See more keywords