Ribosome biogenesis‐based predictive biomarkers in endocrine therapy (Anastrozole) combined with mTOR inhibitor (Vistusertib) in endometrial cancer: translational study from the VICTORIA trial in collaboration with the GINECO group
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13340
Abstract: Resistance of advanced hormone‐dependent endometrial carcinoma to endocrine therapy remains a worldwide clinical issue. We recently reported that the combination of Vistusertib (V, mTOR inhibitor) and Anastrozole (A, aromatase inhibitor) improves the progression‐free rate compared… read more here.
Keywords: ribosome biogenesis; mtor inhibitor; inhibitor; endocrine therapy ... See more keywords
HMGB proteins involved in TOR signaling as general regulators of cell growth by controlling ribosome biogenesis
Sign Up to like & getrecommendations! Published in 2018 at "Current Genetics"
DOI: 10.1007/s00294-018-0842-8
Abstract: The number of ribosomes and their activity need to be highly regulated because their function is crucial for the cell. Ribosome biogenesis is necessary for cell growth and proliferation in accordance with nutrient availability and… read more here.
Keywords: ribosome biogenesis; cell growth; tor; hmgb proteins ... See more keywords
Temporal changes in the markers of ribosome biogenesis in rat soleus muscle under simulated microgravity
Sign Up to like & getrecommendations! Published in 2021 at "Acta Astronautica"
DOI: 10.1016/j.actaastro.2021.05.036
Abstract: Abstract Skeletal muscle inactivity due to real or simulated microgravity results in a significant atrophy of muscle fibers. One of the key causes of disuse atrophy is a decrease in the rate of muscle protein… read more here.
Keywords: muscle; temporal changes; ribosome biogenesis; simulated microgravity ... See more keywords
Combined RNA-Seq with small RNA revealed ribosome biogenesis and oxidative stress associated with cadmium response in carp (Cyprinus carpio L.) Hepato-pancreas
Sign Up to like & getrecommendations! Published in 2020 at "Aquaculture"
DOI: 10.1016/j.aquaculture.2019.734817
Abstract: Abstract Cadmium (Cd) is one of the serious metal pollutants especially for freshwater. The carp fish can live and survive in extremely toxic conditions, providing us a useful model for studying Cd response and regulation.… read more here.
Keywords: response; hepato pancreas; stress; expression ... See more keywords
Nop-7-associated 2 (NSA2) is required for ribosome biogenesis and protein synthesis.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.09.041
Abstract: Ribosome biogenesis is a fundamental cellular process and occurs mainly in the nucleolus in eukaryotes. The process is exceptionally complex and highly regulated by numerous ribosomal and non-ribosomal factors. A recent discovery strengthened the link… read more here.
Keywords: associated nsa2; nop associated; ribosome biogenesis; synthesis ... See more keywords
Diverse Regulators of Human Ribosome Biogenesis Discovered by Changes in Nucleolar Number
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.01.056
Abstract: SUMMARY Ribosome biogenesis is a highly regulated, essential cellular process. Although studies in yeast have established some of the biological principles of ribosome biogenesis, many of the intricacies of its regulation in higher eukaryotes remain… read more here.
Keywords: nucleolar number; ribosome biogenesis; diverse regulators; regulators human ... See more keywords
Noc4L-Mediated Ribosome Biogenesis Controls Activation of Regulatory and Conventional T Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.03.083
Abstract: Regulatory T cell (Treg) activation is crucial for maintaining self-tolerance, but the translational regulation of this process is still poorly understood. Although ribosome biogenesis is considered a housekeeping process, emerging evidence supports the hypothesis that ribosome… read more here.
Keywords: biogenesis controls; biogenesis; noc4l mediated; ribosome biogenesis ... See more keywords
CBFβ-SMMHC regulates ribosomal gene transcription and alters ribosome biogenesis
Sign Up to like & getrecommendations! Published in 2017 at "Leukemia"
DOI: 10.1038/leu.2017.53
Abstract: The core-binding factor (CBF) complex is a heterodimeric transcription factor comprising a CBFβ subunit and a variable DNA-binding RUNX subunit, usually RUNX1 in hematopoietic cells. Aside from its critical hematopoietic functions, CBF regulates the expression… read more here.
Keywords: transcription; cbf smmhc; cbf; smmhc regulates ... See more keywords
Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy
Sign Up to like & getrecommendations! Published in 2021 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-021-00728-8
Abstract: Ribosome biogenesis and protein synthesis are fundamental rate-limiting steps for cell growth and proliferation. The ribosomal proteins (RPs), comprising the structural parts of the ribosome, are essential for ribosome assembly and function. In addition to… read more here.
Keywords: ribosomal proteins; ribosomal defects; targeted therapy; cancer ... See more keywords
Enhanced skeletal muscle ribosome biogenesis, yet attenuated mTORC1 and ribosome biogenesis-related signalling, following short-term concurrent versus single-mode resistance training
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-18887-6
Abstract: Combining endurance training with resistance training (RT) may attenuate skeletal muscle hypertrophic adaptation versus RT alone; however, the underlying mechanisms are unclear. We investigated changes in markers of ribosome biogenesis, a process linked with skeletal… read more here.
Keywords: skeletal muscle; versus; training; ribosome biogenesis ... See more keywords
The nucleolar DExD/H protein Hel66 is involved in ribosome biogenesis in Trypanosoma brucei
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-97020-0
Abstract: The biosynthesis of ribosomes is a complex cellular process involving ribosomal RNA, ribosomal proteins and several further trans-acting factors. DExD/H box proteins constitute the largest family of trans-acting protein factors involved in this process. Several… read more here.
Keywords: protein; involved ribosome; biogenesis; hel66 involved ... See more keywords