Non-equilibrium dynamics of a nascent polypeptide during translation suppress its misfolding
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DOI: 10.1038/s41467-019-10647-6
Abstract: Protein folding can begin co-translationally. Due to the difference in timescale between folding and synthesis, co-translational folding is thought to occur at equilibrium for fast-folding domains. In this scenario, the folding kinetics of stalled ribosome-bound… read more here.
Keywords: ribosome bound; nascent; time; equilibrium ... See more keywords
Ribosome-bound Upf1 forms distinct 80S complexes and conducts mRNA surveillance
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DOI: 10.1261/rna.079416.122
Abstract: Upf1, Upf2, and Upf3, the central regulators of nonsense-mediated mRNA decay (NMD), appear to exercise their NMD functions while bound to elongating ribosomes, and evidence for this conclusion is particularly compelling for Upf1. Hence, we… read more here.
Keywords: mrna surveillance; ribosome bound; upf1 forms; ribosome ... See more keywords
Lso2 is a conserved ribosome-bound protein required for translational recovery in yeast
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DOI: 10.1371/journal.pbio.2005903
Abstract: Ribosome-binding proteins function broadly in protein synthesis, gene regulation, and cellular homeostasis, but the complete complement of functional ribosome-bound proteins remains unknown. Using quantitative mass spectrometry, we identified late-annotated short open reading frame 2 (Lso2)… read more here.
Keywords: recovery; ribosome bound; lso2 conserved; lso2 ... See more keywords