Ribosome collisions induce mRNA cleavage and ribosome rescue in bacteria.
Sign Up to like & getrecommendations! Published in 2022 at "Nature"
DOI: 10.1038/s41586-022-04416-7
Abstract: Ribosome rescue pathways recycle stalled ribosomes and target problematic mRNAs and aborted proteins for degradation1,2. In bacteria, it remains unclear how rescue pathways distinguish ribosomes stalled in the middle of a transcript from actively translating… read more here.
Keywords: ribosome rescue; collisions induce; rescue bacteria; rescue ... See more keywords
Ribosome collisions alter frameshifting at translational reprogramming motifs in bacterial mRNAs
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1910613116
Abstract: Significance Ribosomes move along mRNAs in 3-nucleotide steps as they interpret codons that specify which amino acid is required at each position in the protein. There are multiple examples of genes with DNA sequences that… read more here.
Keywords: translational reprogramming; collisions alter; ribosome collisions; reprogramming motifs ... See more keywords
A comprehensive coverage insurance for cells: revealing links between ribosome collisions, stress responses and mRNA surveillance
Sign Up to like & getrecommendations! Published in 2022 at "RNA Biology"
DOI: 10.1080/15476286.2022.2065116
Abstract: ABSTRACT Cells of metazoans respond to internal and external stressors by activating stress response pathways that aim for re-establishing cellular homoeostasis or, if this cannot be achieved, triggering programmed cell death. Problems during translation, arising… read more here.
Keywords: stress; ribosome collisions; collisions stress; stress responses ... See more keywords
Inverted translational control of eukaryotic gene expression by ribosome collisions
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DOI: 10.1371/journal.pbio.3000396
Abstract: The canonical model of eukaryotic translation posits that efficient translation initiation increases protein expression and mRNA stability. Contrary to this model, we find that increasing initiation rate can decrease both protein expression and stability of… read more here.
Keywords: initiation; gene expression; translation; expression ... See more keywords