Quinoxaline derivatives disrupt the base stacking of hepatitis C virus-internal ribosome entry site RNA: reduce translation and replication.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c9cc06531h
Abstract: RNA-biased small molecules with a monoquinoxaline core target the L-shaped structure of subdomain IIa of Hepatitis C virus internal ribosome entry site (IRES) RNA in proximity to the Mg2+ binding site. The binding event leads… read more here.
Keywords: ribosome entry; internal ribosome; rna; site ... See more keywords
Functional Insights into the Adjacent Stem-Loop in Honey Bee Dicistroviruses That Promotes Internal Ribosome Entry Site-Mediated Translation and Viral Infection
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Virology"
DOI: 10.1128/jvi.01725-17
Abstract: ABSTRACT All viruses must successfully harness the host translational apparatus and divert it toward viral protein synthesis. Dicistroviruses use an unusual internal ribosome entry site (IRES) mechanism whereby the IRES adopts a three-pseudoknot structure that… read more here.
Keywords: ribosome entry; internal ribosome; site; stem loop ... See more keywords
hnRNP Q Regulates Internal Ribosome Entry Site-Mediated fmr1 Translation in Neurons
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Biology"
DOI: 10.1128/mcb.00371-18
Abstract: Fragile X syndrome (FXS) caused by loss of fragile X mental retardation protein (FMRP), is the most common cause of inherited intellectual disability. Numerous studies show that FMRP is an RNA binding protein that regulates… read more here.
Keywords: ribosome entry; mediated fmr1; internal ribosome; fmr1 translation ... See more keywords
IRESpy: an XGBoost model for prediction of internal ribosome entry sites
Sign Up to like & getrecommendations! Published in 2019 at "BMC Bioinformatics"
DOI: 10.1186/s12859-019-2999-7
Abstract: BackgroundInternal ribosome entry sites (IRES) are segments of mRNA found in untranslated regions that can recruit the ribosome and initiate translation independently of the 5′ cap-dependent translation initiation mechanism. IRES usually function when 5′ cap-dependent… read more here.
Keywords: ribosome entry; entry sites; model; xgboost model ... See more keywords
Sequence features of viral and human Internal Ribosome Entry Sites predictive of their activity
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1005734
Abstract: Translation of mRNAs through Internal Ribosome Entry Sites (IRESs) has emerged as a prominent mechanism of cellular and viral initiation. It supports cap-independent translation of select cellular genes under normal conditions, and in conditions when… read more here.
Keywords: ribosome entry; ires activity; internal ribosome; activity ... See more keywords
DDX60 selectively reduces translation off viral type II internal ribosome entry sites
Sign Up to like & getrecommendations! Published in 2022 at "EMBO Reports"
DOI: 10.15252/embr.202255218
Abstract: Co‐opting host cell protein synthesis is a hallmark of many virus infections. In response, certain host defense proteins limit mRNA translation globally, albeit at the cost of the host cell's own protein synthesis. Here, we… read more here.
Keywords: ribosome entry; translation viral; internal ribosome; type ires ... See more keywords
Internal Ribosome Entry Site (IRES)-Mediated Translation and Its Potential for Novel mRNA-Based Therapy Development
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10081865
Abstract: Many conditions can benefit from RNA-based therapies, namely, those targeting internal ribosome entry sites (IRESs) and their regulatory proteins, the IRES trans-acting factors (ITAFs). IRES-mediated translation is an alternative mechanism of translation initiation, known for… read more here.
Keywords: mediated translation; ires mediated; ribosome entry; development ... See more keywords