Ribosome collisions induce mRNA cleavage and ribosome rescue in bacteria.
Sign Up to like & getrecommendations! Published in 2022 at "Nature"
DOI: 10.1038/s41586-022-04416-7
Abstract: Ribosome rescue pathways recycle stalled ribosomes and target problematic mRNAs and aborted proteins for degradation1,2. In bacteria, it remains unclear how rescue pathways distinguish ribosomes stalled in the middle of a transcript from actively translating… read more here.
Keywords: ribosome rescue; collisions induce; rescue bacteria; rescue ... See more keywords
A stalled-ribosome rescue factor Pth3 is required for mitochondrial translation against antibiotics in Saccharomyces cerevisiae
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DOI: 10.1038/s42003-021-01835-6
Abstract: Mitochondrial translation appears to involve two stalled-ribosome rescue factors (srRFs). One srRF is an ICT1 protein from humans that rescues a “non-stop” type of mitochondrial ribosomes (mitoribosomes) stalled on mRNA lacking a stop codon, while… read more here.
Keywords: pth3; saccharomyces cerevisiae; stalled ribosome; ribosome rescue ... See more keywords
The ribosome rescue pathways SsrA-SmpB, ArfA and ArfB mediate tolerance to heat and antibiotic stresses in Azotobacter vinelandii.
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DOI: 10.1093/femsle/fnac104
Abstract: Bacteria have a mechanism to rescue stalled ribosomes known as trans-translation consisting of SsrA, a transfer-messenger RNA (tmRNA), and the small protein SmpB. Other alternative rescue mechanisms mediated by ArfA and ArfB proteins are present… read more here.
Keywords: arfa arfb; arfb; rescue; heat antibiotic ... See more keywords
A New Mechanism for Ribosome Rescue Can Recruit RF1 or RF2 to Nonstop Ribosomes
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DOI: 10.1128/mbio.02436-18
Abstract: Francisella tularensis is a highly infectious intracellular pathogen that kills more than half of infected humans if left untreated. F. tularensis has also been classified as a potential bioterrorism agent with a great risk for… read more here.
Keywords: trans translation; rescue; ribosome rescue; activity ... See more keywords
Mechanism of ribosome rescue by ArfA and RF2
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DOI: 10.7554/elife.23687
Abstract: ArfA rescues ribosomes stalled on truncated mRNAs by recruiting release factor RF2, which normally binds stop codons to catalyze peptide release. We report two 3.2 Å resolution cryo-EM structures – determined from a single sample… read more here.
Keywords: arfa; ribosome rescue; arfa rf2;