Mutational Evolution of Pseudomonas aeruginosa Resistance to Ribosome-Targeting Antibiotics
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DOI: 10.3389/fgene.2018.00451
Abstract: The present work examines the evolutionary trajectories of replicate Pseudomonas aeruginosa cultures in presence of the ribosome-targeting antibiotics tobramycin and tigecycline. It is known that large number of mutations across different genes – and therefore… read more here.
Keywords: pseudomonas aeruginosa; ribosome targeting; evolution; targeting antibiotics ... See more keywords
The Mechanisms of Action of Ribosome-Targeting Peptide Antibiotics
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2018.00048
Abstract: The ribosome is one of the major targets in the cell for clinically used antibiotics. However, the increase in multidrug resistant bacteria is rapidly reducing the effectiveness of our current arsenal of ribosome-targeting antibiotics, highlighting… read more here.
Keywords: mechanisms action; ribosome targeting; targeting peptide; peptide antibiotics ... See more keywords