In vitro selection of ribozyme ligases that use prebiotically plausible 2-aminoimidazole–activated substrates
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DOI: 10.1073/pnas.1914367117
Abstract: Significance Current models for the origin of life include an earlier period when prebiotic chemistry dictated the nonenzymatic copying of RNA polymers, followed by a period of ribozyme-catalyzed reactions using nucleoside-5′-triphosphate (NTP) substrates. Our study… read more here.
Keywords: ribozyme; template; rna; rna substrates ... See more keywords