Trans-cleaving hammerhead ribozyme in specific regions can improve knockdown efficiency in vivo.
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DOI: 10.1002/jcb.30249
Abstract: Trans-cleaving techniques have been most enthusiastically embraced in the development of therapy for genetic diseases, particularly in the correction of monogenic recessive mutations at the messenger RNA level. However, easy degradation and poor catalytic activity… read more here.
Keywords: trans cleaving; ribozyme specific; cleaving hammerhead; hammerhead ribozyme ... See more keywords