Structures of Ric-8B in complex with Gα protein folding clients reveal isoform specificity mechanisms.
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DOI: 10.2139/ssrn.4254228
Abstract: Mammalian Ric-8 proteins act as chaperones to regulate the cellular abundance of heterotrimeric G protein α subunits. The Ric-8A isoform chaperones Gαi/o, Gα12/13, and Gαq/11 subunits, while Ric-8B acts on Gαs/olf subunits. Here, we determined… read more here.
Keywords: protein folding; structures ric; ric complex; complex protein ... See more keywords