RIC-seq for global in situ profiling of RNA–RNA spatial interactions
Sign Up to like & getrecommendations! Published in 2020 at "Nature"
DOI: 10.1038/s41586-020-2249-1
Abstract: Highly structured RNA molecules usually interact with each other, and associate with various RNA-binding proteins, to regulate critical biological processes. However, RNA structures and interactions in intact cells remain largely unknown. Here, by coupling proximity… read more here.
Keywords: seq; rna binding; ric seq; seq global ... See more keywords
Global in situ profiling of RNA-RNA spatial interactions with RIC-seq.
Sign Up to like & getrecommendations! Published in 2021 at "Nature protocols"
DOI: 10.1038/s41596-021-00524-2
Abstract: Emerging evidence has demonstrated that RNA-RNA interactions are vital in controlling diverse biological processes, including transcription, RNA splicing and protein translation. RNA in situ conformation sequencing (RIC-seq) is a technique for capturing protein-mediated RNA-RNA proximal… read more here.
Keywords: rna rna; rna; rna interactions; ric seq ... See more keywords