Correlating uptake and activity of proline-rich antimicrobial peptides in Escherichia coli
Sign Up to like & getrecommendations! Published in 2017 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-017-0496-2
Abstract: AbstractIncreasing death tolls accounted for by antimicrobial drug resistance demand novel antibiotic lead compounds. Among different promising candidate classes, proline-rich antimicrobial peptides (PrAMPs) are very favorable due to their intracellular mechanism, i.e., binding to the 70S… read more here.
Keywords: escherichia coli; correlating uptake; antimicrobial peptides; rich antimicrobial ... See more keywords
The proline-rich antimicrobial peptide Api137 is bactericidal in porcine blood infected ex vivo with a porcine or an human Klebsiella pneumoniae strain.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of global antimicrobial resistance"
DOI: 10.1016/j.jgar.2020.12.012
Abstract: OBJECTIVES Klebsiella (K.) pneumoniae is an emerging invasive pathogen in humans and pigs. Resistance against multiple antibiotics in this species is a major health concern and development of new antibiotics is urgently needed. The objective… read more here.
Keywords: pneumoniae; blood; rich antimicrobial; porcine blood ... See more keywords
Fragments of the Nonlytic Proline-Rich Antimicrobial Peptide Bac5 Kill Escherichia coli Cells by Inhibiting Protein Synthesis
Sign Up to like & getrecommendations! Published in 2018 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00534-18
Abstract: ABSTRACT Unlike most antimicrobial peptides (AMPs), the main mode of action of the subclass of proline-rich antimicrobial peptides (PrAMPs) is not based on disruption of the bacterial membrane. Instead, PrAMPs exploit the inner membrane transporters… read more here.
Keywords: proline rich; protein synthesis; rich antimicrobial; bac5 ... See more keywords
The Trp-rich Antimicrobial Amphiphiles With Intramolecular Aromatic Interactions for the Treatment of Bacterial Infection
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2021.733441
Abstract: Antibiotic resistance is emerging as a hot issue with the abuse and overuse of antibiotics, and the shortage of effective antimicrobial agents against multidrug resistant bacteria creates a huge problem to treat the threatening nosocomial… read more here.
Keywords: antimicrobial amphiphiles; infection; trp rich; aromatic interactions ... See more keywords