Histidine-Rich Glycoprotein Functions as a Dual Regulator of Neutrophil Activity in Horses.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of equine veterinary science"
DOI: 10.1016/j.jevs.2021.103620
Abstract: Histidine-rich glycoprotein (HRG) is an abundant plasma protein that has been identified in most mammals. We first identified whole genome sequence of equine HRG (eHRG) and succeeded to purify eHRG from plasma of horses. Since… read more here.
Keywords: rich glycoprotein; histidine rich; activity; dual regulator ... See more keywords
Investigating Native Metal Ion Binding Sites in Mammalian Histidine-Rich Glycoprotein
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.3c00587
Abstract: Mammalian histidine-rich glycoprotein (HRG) is a highly versatile and abundant blood plasma glycoprotein with a diverse range of ligands that is involved in regulating many essential biological processes, including coagulation, cell adhesion, and angiogenesis. Despite… read more here.
Keywords: glycoprotein; rich glycoprotein; metal; mammalian histidine ... See more keywords
Protein disulfide isomerase cleaves allosteric disulfides in histidine-rich glycoprotein to regulate thrombosis
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-47493-0
Abstract: The essence of difference between hemostasis and thrombosis is that the clotting reaction is a highly fine-tuned process. Vascular protein disulfide isomerase (PDI) represents a critical mechanism regulating the functions of hemostatic proteins. Herein we… read more here.
Keywords: histidine rich; disulfide isomerase; protein disulfide; hrg ... See more keywords
Decreased Levels of Histidine-Rich Glycoprotein and Increased Levels of High-Mobility Group Box 1 are Risk Factors for Refractory Kawasaki Disease.
Sign Up to like & getrecommendations! Published in 2022 at "Modern rheumatology"
DOI: 10.1093/mr/roac040
Abstract: OBJECTIVES Histidine-rich glycoprotein (HRG) and high-mobility group box 1 (HMGB1) regulate the activation of neutrophils and vascular endothelium. The aim of this study was to quantify HRG and HMGB1 levels in patients with Kawasaki disease… read more here.
Keywords: mobility group; group; rich glycoprotein; high mobility ... See more keywords
Overexpression of leucine‐rich α2‐glycoprotein‐1 is a prognostic marker and enhances tumor migration in gastric cancer
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Science"
DOI: 10.1111/cas.13329
Abstract: Gastric cancer is one of the most common malignant tumors. Although improvement in chemotherapy has been achieved, the clinical prognosis of advanced gastric cancer remains poor. Therefore, it is increasingly important to predict the prognosis… read more here.
Keywords: leucine rich; gastric cancer; rich glycoprotein; lrg1 expression ... See more keywords
Circulatory cytokeratin 17, marginal zone B1 protein and leucine-rich α2-glycoprotein-1 as biomarkers for disease severity and fibrosis in systemic sclerosis patients
Sign Up to like & getrecommendations! Published in 2022 at "Biochemia Medica"
DOI: 10.11613/bm.2022.030707
Abstract: Introduction Systemic sclerosis (Ssc) is a multiorgan debilitating autoimmune disease that associates the triad: vascular involvement, tissue fibrosis and profound immune response alterations. Numerous previous studies focused on identification of candidate proteomic Ssc biomarkers using… read more here.
Keywords: systemic sclerosis; leucine rich; rich glycoprotein; marginal zone ... See more keywords
Profiles of histidine-rich glycoprotein associate with age and risk of all-cause mortality
Sign Up to like & getrecommendations! Published in 2020 at "Life Science Alliance"
DOI: 10.26508/lsa.202000817
Abstract: Affinity-based proteomics assays identify particular profiles of the circulating histidine-rich glycoprotein to increase with age and elevated levels to indicate a higher risk of all-cause mortality. Despite recognizing aging as a common risk factor of… read more here.
Keywords: risk; cause mortality; rich glycoprotein; age ... See more keywords
Downregulation of leucine‑rich‑α‑2‑glycoprotein 1 expression is associated with the tumorigenesis of head and neck squamous cell carcinoma.
Sign Up to like & getrecommendations! Published in 2017 at "Oncology reports"
DOI: 10.3892/or.2017.5377
Abstract: Leucine-rich-α-2-glycoprotein 1 (LRG1) is considered as a potential biomarker as it is aberrantly expressed in various malignancies. However, there is limited information regarding its role in head and neck squamous cell carcinoma (HNSCC). In the… read more here.
Keywords: neck squamous; leucine rich; rich glycoprotein; hnscc ... See more keywords
Early change in serum leucine-rich α-2-glycoprotein predicts clinical and endoscopic response in ulcerative colitis
Sign Up to like & getrecommendations! Published in 2024 at "Intestinal Research"
DOI: 10.5217/ir.2023.00135
Abstract: Background/Aims Leucine-rich α-2-glycoprotein (LRG) is a new serum biomarker reflecting the disease activity of ulcerative colitis (UC), but its change during the acute phase has not been enough investigated. Methods Patients with UC who initiated… read more here.
Keywords: week; clinical endoscopic; leucine rich; ulcerative colitis ... See more keywords