Pharmacological aspects of ANGPTL3 and ANGPTL4 inhibitors: new therapeutic approaches for the treatment of atherogenic dyslipidemia.
Sign Up to like & getrecommendations! Published in 2020 at "Pharmacological research"
DOI: 10.1016/j.phrs.2020.104653
Abstract: Among the determinants of atherosclerotic cardiovascular disease (ASCVD), genetic and experimental evidence has provided data on a major role of angiopoietin-like proteins 3 and 4 (ANGPTL3 and ANGPTL4) in regulating the activity of lipoprotein lipase… read more here.
Keywords: rich lipoproteins; angptl3 angptl4; treatment; density lipoprotein ... See more keywords
Metabolism of triglyceride-rich lipoproteins in health and dyslipidaemia
Sign Up to like & getrecommendations! Published in 2022 at "Nature Reviews Cardiology"
DOI: 10.1038/s41569-022-00676-y
Abstract: Accumulating evidence points to the causal role of triglyceride-rich lipoproteins and their cholesterol-enriched remnants in atherogenesis. Genetic studies in particular have not only revealed a relationship between plasma triglyceride levels and the risk of atherosclerotic… read more here.
Keywords: plasma triglyceride; triglyceride rich; disease; triglyceride ... See more keywords
A Meal Rich in Palm Oil or Butter Modifies the Sphingolipid Profile of Postprandial Triglyceride-Rich Lipoproteins From Type 2 Diabetic Patients
Sign Up to like & getrecommendations! Published in 2022 at "Current Developments in Nutrition"
DOI: 10.1093/cdn/nzac057.016
Abstract: Abstract Objectives Elevated concentrations of triglyceride-rich lipoproteins (TGRL) in the fasting and postprandial states are a risk factor for cardiovascular events in type 2 diabetes (T2D). Dyslipidemia in T2D is associated with modifications in the… read more here.
Keywords: triglyceride rich; palm; tgrl; rich lipoproteins ... See more keywords
Triglyceride-rich lipoproteins and their remnants: metabolic insights, role in atherosclerotic cardiovascular disease, and emerging therapeutic strategies-a consensus statement from the European Atherosclerosis Society.
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DOI: 10.1093/eurheartj/ehab551
Abstract: Recent advances in human genetics, together with a large body of epidemiologic, preclinical, and clinical trial results, provide strong support for a causal association between triglycerides (TG), TG-rich lipoproteins (TRL), and TRL remnants, and increased… read more here.
Keywords: role atherosclerotic; atherosclerotic cardiovascular; rich lipoproteins; statement ... See more keywords
Triglyceride-rich lipoproteins, remnant-cholesterol, and atherosclerotic cardiovascular disease
Sign Up to like & getrecommendations! Published in 2023 at "Current Opinion in Lipidology"
DOI: 10.1097/mol.0000000000000875
Abstract: Purpose of review Despite indisputable role of LDL-C lowering, a considerable residual risk for atherosclerotic cardiovascular disease (ASCVD) persists. The precise mechanism(s) underlying this phenomenon remain unclear. Triglyceride-rich lipoproteins (TRL) appear to be one of… read more here.
Keywords: triglyceride rich; cardiovascular disease; rich lipoproteins; atherosclerotic cardiovascular ... See more keywords
The fatty acids from LPL-mediated processing of triglyceride-rich lipoproteins are taken up rapidly by cardiomyocytes
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Lipid Research"
DOI: 10.1194/jlr.ilr120000783
Abstract: REAGENTS: Mixed fatty acids (U-D, 96–98%) (Cambridge Isotope Laboratories). The lipolytic processing of triglyceride-rich lipoproteins (TRLs) by lipoprotein lipase has been studied at the biochemical level for >60 years (1, 2), but until recently it… read more here.
Keywords: processing triglyceride; triglyceride rich; rich lipoproteins; secondary ions ... See more keywords
Effect of functional sympathetic nervous system impairment of the liver and abdominal visceral adipose tissue on circulating triglyceride-rich lipoproteins
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0173934
Abstract: Background Interruption of sympathetic innervation to the liver and visceral adipose tissue (VAT) in animal models has been reported to reduce VAT lipolysis and hepatic secretion of very low density lipoprotein (VLDL) and concentrations of… read more here.
Keywords: visceral adipose; rich lipoproteins; triglyceride rich; sympathetic nervous ... See more keywords
Triglyceride-Rich Lipoproteins as a Source of Proinflammatory Lipids in the Arterial Wall.
Sign Up to like & getrecommendations! Published in 2019 at "Current medicinal chemistry"
DOI: 10.2174/0929867325666180530094819
Abstract: Apolipoprotein B -containing lipoproteins include triglyceride-rich lipoproteins (chylomicrons and their remnants, and very low-density lipoproteins and their remnants) and cholesterol-rich low-density lipoprotein particles. Of these, lipoproteins having sizes below 70-80 nm may enter the arterial… read more here.
Keywords: rich lipoproteins; triglyceride rich; arterial wall; lipids arterial ... See more keywords
The Roles of ApoC-III on the Metabolism of Triglyceride-Rich Lipoproteins in Humans
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2020.00474
Abstract: Cardiovascular disease (CVD) is the leading cause of death globally. It is well-established based on evidence accrued during the last three decades that high plasma concentrations of cholesterol-rich atherogenic lipoproteins are causatively linked to CVD,… read more here.
Keywords: rich lipoproteins; triglyceride rich; roles apoc; iii metabolism ... See more keywords