The π Configuration of the WWW Motif of a Short Trp-Rich Peptide Is Critical for Targeting Bacterial Membranes, Disrupting Preformed Biofilms, and Killing Methicillin-Resistant Staphylococcus aureus.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemistry"
DOI: 10.1021/acs.biochem.7b00456
Abstract: Tryptophan-rich peptides, being short and suitable for large-scale chemical synthesis, are attractive candidates for developing a new generation of antimicrobials to combat antibiotic-resistant bacteria (superbugs). Although there are numerous pictures of the membrane-bound structure of… read more here.
Keywords: rich peptide; www motif; trp; trp rich ... See more keywords
A glycine-serine-alanine-rich peptide ameliorates Alzheimer-type neurodegeneration.
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DOI: 10.1111/bph.16048
Abstract: Repeated amino acid sequences in proteins are widely found, and the glycine–serine–alanine repeat is an element with a general propensity to form β‐sheet aggregates as found in key pathological factors, in several neurodegenerative diseases. Such… read more here.
Keywords: rich peptide; glycine serine; serine alanine; alanine rich ... See more keywords
A New Regioselective Synthesis of the Cysteine-Rich Peptide Linaclotide
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28031007
Abstract: Linaclotide is a 14-amino acid residue peptide approved by the FDA for the treatment of irritable bowel syndrome with constipation (IBS-C), which activates guanylate cyclase C to accelerate intestinal transit. Here we show a new… read more here.
Keywords: synthesis cysteine; cysteine rich; synthesis; regioselective synthesis ... See more keywords