Insight into the Mechanism of Action and Peptide‐Membrane Interactions of Aib‐Rich Peptides: Multitechnique Experimental and Theoretical Analysis
Sign Up to like & getrecommendations! Published in 2021 at "Chembiochem"
DOI: 10.1002/cbic.202000834
Abstract: The increase in resistant bacterial strains necessitates the identification of new antimicrobial molecules. Antimicrobial peptides (AMPs) are an attractive option because of evidence that bacteria cannot easily develop resistance to AMPs. The peptaibols, a class… read more here.
Keywords: mechanism; aib rich; rich peptides; mechanism action ... See more keywords
Conjugates of adenosine mimetics and arginine‐rich peptides serve as inhibitors and fluorescent probes but not as long‐lifetime photoluminescent probes for protein arginine methyltransferases
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Peptide Science"
DOI: 10.1002/psc.3456
Abstract: The conjugates of an adenosine mimetic and oligo‐l‐arginine or oligo‐d‐arginine (ARCs) were initially designed in our research group as inhibitors and photoluminescent probes targeting basophilic protein kinases. Here, we explored a panel of ARCs and… read more here.
Keywords: protein arginine; rich peptides; photoluminescent probes; arginine rich ... See more keywords
Peptidomic Identification of Cysteine-Rich Peptides from Plants.
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DOI: 10.1007/978-1-4939-7537-2_26
Abstract: Plant cysteine-rich peptides (CRPs) constitute a majority of plant-derived peptides with high molecular diversity. This protocol describes a rapid and efficient peptidomic approach to identify a whole spectrum of CRPs in a plant extract and… read more here.
Keywords: identification cysteine; peptides plants; rich peptides; cysteine rich ... See more keywords
Ginsentides: Cysteine and Glycine-rich Peptides from the Ginseng Family with Unusual Disulfide Connectivity
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DOI: 10.1038/s41598-018-33894-x
Abstract: Ginseng, a popular and valuable traditional medicine, has been used for centuries to maintain health and treat disease. Here we report the discovery and characterization of ginsentides, a novel family of cysteine and glycine-rich peptides… read more here.
Keywords: rich peptides; glycine rich; cysteine glycine; disulfide connectivity ... See more keywords
An environmentally sustainable biomimetic production of cyclic disulfide-rich peptides
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DOI: 10.1039/d0gc01366h
Abstract: Macrocyclic, disulfide-rich peptides have found widespread applications in drug design and development. Current peptide production strategies rely heavily on solid phase peptide synthesis (SPPS) requiring large amounts of hazardous/toxic reagents and solvents which have negative… read more here.
Keywords: production; disulfide rich; production cyclic; rich peptides ... See more keywords
An evolution-inspired strategy to design disulfide-rich peptides tolerant to extensive sequence manipulation
Sign Up to like & getrecommendations! Published in 2021 at "Chemical Science"
DOI: 10.1039/d1sc02952e
Abstract: Natural disulfide-rich peptides (DRPs) are valuable scaffolds for the development of new bioactive molecules and therapeutics. However, there are only a limited number of topologically distinct DRP folds in nature, and most of them suffer… read more here.
Keywords: evolution inspired; strategy design; disulfide; disulfide rich ... See more keywords
Selection and evolution of disulfide-rich peptides via cellular protein quality control
Sign Up to like & getrecommendations! Published in 2023 at "Chemical Science"
DOI: 10.1039/d2sc05343h
Abstract: Disulfide-rich peptides (DRPs) are an interesting and promising molecular format for drug discovery and development. However, the engineering and application of DRPs rely on the foldability of the peptides into specific structures with correct disulfide… read more here.
Keywords: protein quality; quality control; rich peptides; disulfide rich ... See more keywords
Residual Dipolar Couplings for Resolving Cysteine Bridges in Disulfide-Rich Peptides
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2019.00889
Abstract: Disulfide bridges in proteins are formed by the oxidation of pairs of cysteine residues. These cross-links play a critical role in stabilizing the 3D-structure of small disulfide rich polypeptides such as hormones and venom toxins.… read more here.
Keywords: resolution; residual dipolar; cysteine; disulfide rich ... See more keywords
Cationic Arginine-Rich Peptides (CARPs): A Novel Class of Neuroprotective Agents With a Multimodal Mechanism of Action
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2020.00108
Abstract: There are virtually no clinically available neuroprotective drugs for the treatment of acute and chronic neurological disorders, hence there is an urgent need for the development of new neuroprotective molecules. Cationic arginine-rich peptides (CARPs) are… read more here.
Keywords: arginine rich; cationic arginine; class; peptides carps ... See more keywords
Membrane Internalization Mechanisms and Design Strategies of Arginine-Rich Cell-Penetrating Peptides
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23169038
Abstract: Cell-penetrating peptides (CPPs) have been discovered to deliver chemical drugs, nucleic acids, and macromolecules to permeate cell membranes, creating a novel route for exogenous substances to enter cells. Up until now, various sequence structures and… read more here.
Keywords: cell; rich peptides; cell penetrating; arginine rich ... See more keywords
Enhanced Molecular Networking Shows Microbacterium sp. V1 as a Factory of Antioxidant Proline-Rich Peptides
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DOI: 10.3390/md21040256
Abstract: Two linear proline-rich peptides (1–2), bearing an N-terminal pyroglutamate, were isolated from the marine bacterium Microbacterium sp. V1, associated with the marine sponge Petrosia ficiformis, collected in the volcanic CO2 vents in Ischia Island (South… read more here.
Keywords: enhanced molecular; rich peptides; proline rich; molecular networking ... See more keywords