LRRK2‐mediated Rab10 phosphorylation in immune cells from Parkinson's disease patients
Sign Up to like & getrecommendations! Published in 2019 at "Movement Disorders"
DOI: 10.1002/mds.27601
Abstract: Leucine‐rich repeat kinase 2 is a potential therapeutic target for the treatment of Parkinson's disease, and clinical trials of leucine‐rich repeat kinase 2 inhibitors are in development. The objective of this study was to evaluate… read more here.
Keywords: parkinson disease; rich repeat; repeat kinase; leucine rich ... See more keywords
Genetic analysis of nucleotide-binding leucine-rich repeat (NLR) receptors in multiple sclerosis
Sign Up to like & getrecommendations! Published in 2020 at "Immunogenetics"
DOI: 10.1007/s00251-020-01170-w
Abstract: Genetic and functional analyses of the inflammasome suggest a role for this multiprotein complex in the biological mechanisms leading to the onset and progression of multiple sclerosis (MS). Nucleotide-binding, leucine-rich repeat (NLR) receptors trigger the… read more here.
Keywords: nlr receptors; multiple sclerosis; rich repeat; leucine rich ... See more keywords
The leucine-rich repeat domain of human peroxidasin 1 promotes binding to laminin in basement membranes.
Sign Up to like & getrecommendations! Published in 2020 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2020.108443
Abstract: Human peroxidasin 1 (PXDN) is a homotrimeric multidomain heme peroxidase and essential for tissue development and architecture. It has a biosynthetic function and catalyses the hypobromous acid-mediated formation of specific covalent sulfilimine (SN) bonds, which… read more here.
Keywords: leucine rich; repeat domain; human peroxidasin; basement membranes ... See more keywords
The heterozygous R1441C mutation of leucine-rich repeat kinase 2 gene in a Chinese patient with Parkinson disease: A five-year follow-up and literatures review
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the Neurological Sciences"
DOI: 10.1016/j.jns.2016.12.009
Abstract: BACKGROUND Leucine-rich repeat kinase 2 gene (LRRK2) was recognized associated with both familial and sporadic Parkinson Disease (PD). Seven missense mutations (G2019S, R1441C, R1441G, R1441H, Y1699C, I2020T, N1437H) of it have been confirmed disease- causing.… read more here.
Keywords: kinase gene; leucine rich; disease; repeat kinase ... See more keywords
The Development and Design Strategy of Leucine-Rich Repeat Kinase 2 Inhibitors: Promising Therapeutic Agents for Parkinson's Disease.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01552
Abstract: Parkinson's disease (PD) is a progressive neurodegenerative disorder affecting millions of people worldwide. Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) are the most common genetic risk factor for PD. Elevated LRRK2 kinase… read more here.
Keywords: repeat kinase; leucine rich; parkinson disease; kinase ... See more keywords
Molecular Recognition of Muramyl Dipeptide Occurs in the Leucine-rich Repeat Domain of Nod2.
Sign Up to like & getrecommendations! Published in 2017 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.6b00154
Abstract: Genetic mutations in the innate immune receptor nucleotide-binding oligomerization domain-containing 2 (Nod2) have demonstrated increased susceptibility to Crohn's disease, an inflammatory bowel disease that is hypothesized to be accompanied by changes in the gut microbiota.… read more here.
Keywords: leucine rich; lrr domain; rich repeat; muramyl dipeptide ... See more keywords
Leucine-Rich Repeat Kinase 2 (Lrrk2)-Sensitive Na+/K+ ATPase Activity in Dendritic Cells
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep41117
Abstract: Leucine-rich repeat kinase 2 (Lrrk2) has been implicated in the pathophysiology of Parkinson’s disease. Lrrk2 is expressed in diverse cells including neurons and dendritic cells (DCs). In DCs Lrrk2 was shown to up-regulate Na+/Ca2+-exchanger activity.… read more here.
Keywords: atpase; leucine rich; dendritic cells; rich repeat ... See more keywords
From structure to ætiology: a new window on the biology of leucine-rich repeat kinase 2 and Parkinson's disease
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical Journal"
DOI: 10.1042/bcj20210383
Abstract: Since the discovery of mutations in leucine-rich repeat kinase 2 (LRRK2) as an underlying genetic cause for the development of Parkinson's disease (PD) in 2004 (Neuron 44, 601–607; Neuron 44, 595–600), and subsequent efforts to… read more here.
Keywords: repeat kinase; kinase; biology; rich repeat ... See more keywords
Leucine-rich repeat kinase 2 inhibitors: a patent review (2014-present)
Sign Up to like & getrecommendations! Published in 2020 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2020.1729354
Abstract: ABSTRACT Introduction: Disease-modifying treatment for Parkinson’s disease (PD) to halt or revert the disease progression remains an unmet medical need. LRRK2 kinase activity is abnormally elevated in PD patients carrying LRRK2 mutations, with G2019S as… read more here.
Keywords: leucine rich; kinase; disease; review ... See more keywords
Leucine-rich repeat kinase 2 (LRRK2): an update on the potential therapeutic target for Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2022.2082937
Abstract: ABSTRACT Mutations in Leucine-rich repeat kinase 2 (LRRK2) are a risk factor for and a cause of sporadic and familial Parkinson’s disease (PD), respectively. These mutations are some of the most common genetic contributors to… read more here.
Keywords: leucine rich; parkinson disease; kinase; rich repeat ... See more keywords
Serine-rich repeat proteins from gut microbes
Sign Up to like & getrecommendations! Published in 2019 at "Gut Microbes"
DOI: 10.1080/19490976.2019.1602428
Abstract: ABSTRACT Serine-rich repeat proteins (SRRPs) have emerged as an important group of cell surface adhesins found in a growing number of Gram-positive bacteria. Studies focused on SRRPs from streptococci and staphylococci demonstrated that these proteins… read more here.
Keywords: gut microbes; rich repeat; repeat proteins; serine rich ... See more keywords