Distinct immune signatures in chronic lymphocytic leukemia and Richter syndrome
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DOI: 10.1038/s41408-021-00477-5
Abstract: Richter syndrome (RS) refers to transformation of chronic lymphocytic leukemia (CLL) to an aggressive lymphoma, most commonly diffuse large B-cell lymphoma. RS is known to be associated with a number of genetic alterations such as… read more here.
Keywords: distinct immune; cll; lymphocytic leukemia; immune signatures ... See more keywords
Richter’s syndrome of T-cell lineage (T rex lymphoma)
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DOI: 10.1080/03007995.2020.1713072
Abstract: Abstract By definition, Richter’s syndrome represents the transformation of low-grade B-cell lymphoma into high-grade B-cell lymphoma, usually refractory to treatment. Exceptional cases of transformation into very aggressive mature T-cell lymphomas have been described as an… read more here.
Keywords: lymphoma; cell lymphoma; grade cell; cell ... See more keywords
Cardiac Richter's syndrome: a rare case of chronic lymphocytic leukaemia transformation.
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DOI: 10.1093/eurheartj/ehad184
Abstract: A 71–year–old woman with chronic lymphocytic leukaemia (CLL) presented to our Cardiology clinic complaining of recent–onset chest pain and dysphonia. Physical examination and ECG were normal. A blood test revealed high levels of high–sensitivity troponin… read more here.
Keywords: cll; richter syndrome; lymphocytic leukaemia; chronic lymphocytic ... See more keywords
Richter's syndrome of the central nervous system diagnosed concurrently with chronic lymphocytic leukaemia
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DOI: 10.1097/md.0000000000012701
Abstract: Rationale: Central nervous system (CNS) infiltration of Richter's syndrome (RS) is rare and only a few cases were discussed. Of these published cases, either they were accompanied with lymph node involvement or with a history… read more here.
Keywords: nervous system; central nervous; diagnosed concurrently; chronic lymphocytic ... See more keywords
Richter syndrome presenting as Sister Mary Joseph umbilical nodule
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DOI: 10.1111/bjh.14786
Abstract: A 74-year-old man was referred from another hospital with a possible incarcerated hernia after presenting with nausea, vomiting, weight loss and an umbilical protuberance (top left). His past medical history included chronic lymphocytic leukaemia (CLL)… read more here.
Keywords: sister mary; mary joseph; umbilical nodule; nodule ... See more keywords
Clonally unrelated Richter syndrome are truly de novo diffuse large B‐cell lymphomas with a mutational profile reminiscent of clonally related Richter syndrome
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Haematology"
DOI: 10.1111/bjh.18352
Abstract: Richter syndrome (RS) is mostly due to the direct transformation of the chronic lymphocytic leukaemia (CLL) clone, as documented by the same immunoglobulin heavy‐chain variable region (IGHV) rearrangement in both CLL and RS cells. In… read more here.
Keywords: cll phase; clonally unrelated; richter; richter syndrome ... See more keywords
Abstract 3795: Deciphering the in vivo roles of a novel long non-coding RNA in chronic lymphocytic leukemia and Richter syndrome
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3795
Abstract: The ultraconserved regions (UCRs) are the genomic segments manifesting perfect conservation between the orthologous genomes of humans, rats, and mice that get transcribed into mono-exonic long non-coding RNAs (lncRNAs) known as transcribed ultraconserved regions (T-UCRs).… read more here.
Keywords: long non; lymphocytic leukemia; richter syndrome; chronic lymphocytic ... See more keywords
Synergistic efficacy of dual PI3K-d/g inhibitor Duvelisib with Bcl2 inhibitor Venetoclax in Richter's Syndrome PDX models.
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DOI: 10.1182/blood.2020010187
Abstract: A small subset of cases of chronic lymphocytic leukemia undergoes transformation to diffuse large B-cell lymphoma, Richter's Syndrome (RS), which is associated with a poor prognosis. Conventional chemotherapy results in limited responses, underlining the need… read more here.
Keywords: pi3k; inhibitor; efficacy dual; dual pi3k ... See more keywords
Genetic and Molecular Characterization of Novel Richter Syndrome Patient-Derived Xenograft Models
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DOI: 10.1182/blood.v130.suppl_1.4297.4297
Abstract: Background. Richter syndrome (RS) is the transformation of a pre-existing chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) into an aggressive lymphoma, most commonly a diffuse large B-cell lymphoma (DLBCL), an event which occurs in approximately… read more here.
Keywords: pdx models; biology; patient derived; consultancy ... See more keywords
Rapid and complete response to idelalisib in a case of Richter syndrome
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DOI: 10.2147/ott.s187459
Abstract: Richter syndrome (RS) is an aggressive lymphoma arising on the back of chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) and is the most common B-cell malignancy in the Western world. In the majority of cases,… read more here.
Keywords: idelalisib; response; richter syndrome; complete response ... See more keywords
Cellular Therapy in High-Risk Relapsed/Refractory Chronic Lymphocytic Leukemia and Richter Syndrome
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DOI: 10.3389/fonc.2022.888109
Abstract: Despite the development of highly effective, targeted inhibitors of B-cell proliferation and anti-apoptotic pathways in chronic lymphocytic leukemia (CLL), these treatments are not curative, and many patients will develop either intolerance or resistance to these… read more here.
Keywords: lymphocytic leukemia; high risk; therapy; cellular therapy ... See more keywords