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   Articles with "richter transformation" as a keyword



Diagnosis of Richter transformation in chronic lymphocytic leukemia: histology tips the scales

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recommendations! Published in 2018 at "Annals of Hematology"

DOI: 10.1007/s00277-018-3390-x

Abstract: Development of diffuse large B-cell lymphoma in chronic lymphocytic leukemia, so-called Richter transformation (RT), occurs in 2–5% of patients and is associated with poor outcome. The clinical features of RT are fairly non-specific and unable… read more here.

Keywords: lymphocytic leukemia; diagnosis; transformation; richter transformation ... See more keywords

Treatment of Richter’s Transformation with Novel Therapies

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recommendations! Published in 2024 at "Current Hematologic Malignancy Reports"

DOI: 10.1007/s11899-023-00721-8

Abstract: Purpose of Review This review presents recently published clinical trial data and ongoing investigations regarding the treatment of Richter’s transformation (RT). Recent Findings Recently, numerous approaches have been investigated for the treatment of RT including:… read more here.

Keywords: treatment richter; treatment; richter transformation; targeted agents ... See more keywords

Richter’s Transformation

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recommendations! Published in 2022 at "Current Oncology Reports"

DOI: 10.1007/s11912-022-01274-4

Abstract: Richter’s transformation (RT) occurs when chronic (CLL) transforms into an aggressive lymphoma. Despite improvements in the treatment of CLL, prognosis for RT remains poor. Here, we review current literature of RT, with a focus on… read more here.

Keywords: treatment; oncology; richter; richter transformation ... See more keywords

Clinical utility of chromosomal microarray in establishing clonality and high risk features in patients with Richter transformation.

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recommendations! Published in 2021 at "Cancer genetics"

DOI: 10.1016/j.cancergen.2021.10.003

Abstract: Richter transformation (RT) refers to the development of an aggressive lymphoma in patients with pre-existing chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). It carries a poor prognosis secondary to poor response to therapy or rapid disease… read more here.

Keywords: patients richter; chromosomal microarray; transformation; richter transformation ... See more keywords
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Richter transformation in the oral and maxillofacial area: report of 2 cases and literature review.

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recommendations! Published in 2020 at "Oral surgery, oral medicine, oral pathology and oral radiology"

DOI: 10.1016/j.oooo.2020.02.016

Abstract: Richter transformation (RT) is a term used to refer to the development of an aggressive lymphoma, usually of diffuse large B-cell lymphoma type, in a patient with a history of chronic lymphocytic leukemia. It may… read more here.

Keywords: area report; transformation oral; maxillofacial area; oral maxillofacial ... See more keywords

Unusual Illustration of Richter Transformation in Chronic Lymphocytic Leukemia on FDG PET/CT.

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recommendations! Published in 2022 at "Clinical nuclear medicine"

DOI: 10.1097/rlu.0000000000004125

Abstract: ABSTRACT A man with history of chronic lymphocytic leukemia (CLL) in remission had multiple rapidly growing lumps in recent 2 months. FDG PET/CT demonstrated disseminated FDG-avid nodal and extranodal lesions including those in unusual locations… read more here.

Keywords: lymphocytic leukemia; fdg pet; chronic lymphocytic; richter transformation ... See more keywords

Outcomes of Hodgkin variant Richter transformation in chronic lymphocytic leukaemia and small lymphocytic lymphoma in British Columbia

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recommendations! Published in 2022 at "British Journal of Haematology"

DOI: 10.1111/bjh.18241

Abstract: Hodgkin variant Richter transformation (HvRT) is a rare and challenging complication of chronic lymphocytic leukaemia (CLL) for which information on prognostic factors and treatment approaches remain limited. We analysed characteristics and survival outcomes of a… read more here.

Keywords: hodgkin variant; variant richter; hvrt; richter transformation ... See more keywords

Long‐term remission in a patient with relapsed Richter's transformation treated with CD19‐directed chimeric antigen‐receptor T‐cells after allogeneic stem cell transplantation

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recommendations! Published in 2024 at "European Journal of Haematology"

DOI: 10.1111/ejh.14182

Abstract: Patients with Richter's transformation of chronic lymphocytic leukemia (CLL) to diffuse large B‐cell lymphoma (DLBCL‐RT) face a dismal prognosis. A 51‐year‐old female patient diagnosed with CLL with deletion (17p) in 2009. CLL treatment included chemoimmunotherapy… read more here.

Keywords: cell transplantation; stem cell; cell; richter transformation ... See more keywords
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A Richter transformation PD-1 block party.

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recommendations! Published in 2017 at "Blood"

DOI: 10.1182/blood-2017-05-781229

Abstract: In this issue of Blood, Ding et al demonstrated anti–programmed death 1 (anti–PD-1) responses that may benefit chronic lymphocytic leukemia (CLL) patients with Richter transformation (RT) but did not show activity in non-RT CLL patients.1 read more here.

Keywords: transformation block; richter transformation; block party; transformation ... See more keywords

Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1.

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recommendations! Published in 2021 at "Blood"

DOI: 10.1182/blood.2020005734

Abstract: Richter's transformation (RT) is an aggressive lymphoma that occurs upon progression from chronic lymphocytic leukemia (CLL). Transformation has been associated with genetic aberrations in the CLL phase involving TP53, CDKN2A, MYC, and NOTCH1; however, a… read more here.

Keywords: aggressive lymphoma; cll; overactivation; transformation ... See more keywords

International Consensus Statement on Diagnosis, Evaluation, and Research of Richter Transformation: the ERIC Recommendations.

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recommendations! Published in 2025 at "Blood"

DOI: 10.1182/blood.2024028064

Abstract: Richter transformation (RT) is defined as an aggressive lymphoma emerging in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL). Despite novel therapeutics developed in CLL, RT is associated with poor outcomes. In light of recent… read more here.

Keywords: consensus; richter transformation; research; cll ... See more keywords