Diagnosis of Richter transformation in chronic lymphocytic leukemia: histology tips the scales
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Hematology"
DOI: 10.1007/s00277-018-3390-x
Abstract: Development of diffuse large B-cell lymphoma in chronic lymphocytic leukemia, so-called Richter transformation (RT), occurs in 2–5% of patients and is associated with poor outcome. The clinical features of RT are fairly non-specific and unable… read more here.
Keywords: lymphocytic leukemia; diagnosis; transformation; richter transformation ... See more keywords
Richter’s Transformation
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DOI: 10.1007/s11912-022-01274-4
Abstract: Richter’s transformation (RT) occurs when chronic (CLL) transforms into an aggressive lymphoma. Despite improvements in the treatment of CLL, prognosis for RT remains poor. Here, we review current literature of RT, with a focus on… read more here.
Keywords: treatment; oncology; richter; richter transformation ... See more keywords
Clinical utility of chromosomal microarray in establishing clonality and high risk features in patients with Richter transformation.
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DOI: 10.1016/j.cancergen.2021.10.003
Abstract: Richter transformation (RT) refers to the development of an aggressive lymphoma in patients with pre-existing chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). It carries a poor prognosis secondary to poor response to therapy or rapid disease… read more here.
Keywords: patients richter; chromosomal microarray; transformation; richter transformation ... See more keywords
Richter transformation in the oral and maxillofacial area: report of 2 cases and literature review.
Sign Up to like & getrecommendations! Published in 2020 at "Oral surgery, oral medicine, oral pathology and oral radiology"
DOI: 10.1016/j.oooo.2020.02.016
Abstract: Richter transformation (RT) is a term used to refer to the development of an aggressive lymphoma, usually of diffuse large B-cell lymphoma type, in a patient with a history of chronic lymphocytic leukemia. It may… read more here.
Keywords: area report; transformation oral; maxillofacial area; oral maxillofacial ... See more keywords
Unusual Illustration of Richter Transformation in Chronic Lymphocytic Leukemia on FDG PET/CT.
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DOI: 10.1097/rlu.0000000000004125
Abstract: ABSTRACT A man with history of chronic lymphocytic leukemia (CLL) in remission had multiple rapidly growing lumps in recent 2 months. FDG PET/CT demonstrated disseminated FDG-avid nodal and extranodal lesions including those in unusual locations… read more here.
Keywords: lymphocytic leukemia; fdg pet; chronic lymphocytic; richter transformation ... See more keywords
Outcomes of Hodgkin variant Richter transformation in chronic lymphocytic leukaemia and small lymphocytic lymphoma in British Columbia
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Haematology"
DOI: 10.1111/bjh.18241
Abstract: Hodgkin variant Richter transformation (HvRT) is a rare and challenging complication of chronic lymphocytic leukaemia (CLL) for which information on prognostic factors and treatment approaches remain limited. We analysed characteristics and survival outcomes of a… read more here.
Keywords: hodgkin variant; variant richter; hvrt; richter transformation ... See more keywords
A Richter transformation PD-1 block party.
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood-2017-05-781229
Abstract: In this issue of Blood, Ding et al demonstrated anti–programmed death 1 (anti–PD-1) responses that may benefit chronic lymphocytic leukemia (CLL) patients with Richter transformation (RT) but did not show activity in non-RT CLL patients.1 read more here.
Keywords: transformation block; richter transformation; block party; transformation ... See more keywords
Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1.
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DOI: 10.1182/blood.2020005734
Abstract: Richter's transformation (RT) is an aggressive lymphoma that occurs upon progression from chronic lymphocytic leukemia (CLL). Transformation has been associated with genetic aberrations in the CLL phase involving TP53, CDKN2A, MYC, and NOTCH1; however, a… read more here.
Keywords: aggressive lymphoma; cll; overactivation; transformation ... See more keywords
A phase 2 study of nivolumab combined with ibrutinib in patients with diffuse large B-cell Richter transformation of CLL
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DOI: 10.1182/bloodadvances.2022008790
Abstract: Key Points • Patients with DLBCL Richter transformation of CLL have a poor prognosis, especially if they have had prior BTKi exposure.• Nivolumab and ibrutinib combination therapy is a safe and potential treatment option in… read more here.
Keywords: richter transformation; study nivolumab; phase study; transformation cll ... See more keywords
Richter Transformation Arising From Chronic Lymphocytic Leukemia.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical journal of oncology nursing"
DOI: 10.1188/22.cjon.14-17
Abstract: This article presents a case of a patient diagnosed with an indolent form of chronic lymphocytic leukemia (CLL). He was being followed with close observation when he was diagnosed with Richter transformation, an aggressive lymphoma… read more here.
Keywords: chronic lymphocytic; transformation; lymphocytic leukemia; richter transformation ... See more keywords
Cellular Therapies in Chronic Lymphocytic Leukemia and Richter’s Transformation: Recent Developments in Chimeric Antigen Receptor T-Cells, Natural Killer Cells, and Allogeneic Stem Cell Transplant
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15061838
Abstract: Simple Summary Here, we present a review of cellular therapies that have been used in both chronic lymphocytic leukemia and Richter’s transformation. We will review the data behind allogeneic hematopoietic stem cell transplantation in the… read more here.
Keywords: cell; lymphocytic leukemia; cellular therapies; richter transformation ... See more keywords