Sensitivity of Kupffer cells and liver sinusoidal endothelial cells to ricin toxin and ricin toxin–Ab complexes
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.4a0419-123r
Abstract: Ricin toxin is a plant‐derived, ribosome‐inactivating protein that is rapidly cleared from circulation by Kupffer cells (KCs) and liver sinusoidal endothelial cells (LSECs)—with fatal consequences. Rather than being inactivated, ricin evades normal degradative pathways and… read more here.
Keywords: ricin; ricin toxin; kupffer cells; liver sinusoidal ... See more keywords
Quantitative detection of ricin in beverages using trypsin/Glu-C tandem digestion coupled with ultra-high-pressure liquid chromatography-tandem mass spectrometry
Sign Up to like & getrecommendations! Published in 2020 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-020-03030-8
Abstract: The toxic protein of ricin has drawn wide attention in recent years as a potential bioterrorism agent due to its high toxicity and wide availability. For the verification of the potential anti-terrorism activities, it is… read more here.
Keywords: ricin; digestion; trypsin glu; marker peptides ... See more keywords
Extended therapeutic window for post‐exposure treatment of ricin intoxication conferred by the use of high‐affinity antibodies
Sign Up to like & getrecommendations! Published in 2017 at "Toxicon"
DOI: 10.1016/j.toxicon.2017.01.009
Abstract: ABSTRACT The plant toxin ricin is considered a potential bioterror agent against which there is no available antidote. To date, neutralizing antibodies are the most promising post‐exposure treatment for ricin intoxication, yet so far they… read more here.
Keywords: exposure treatment; ricin; post exposure;
Small molecule inhibitors targeting the interaction of ricin toxin A subunit with ribosomes.
Sign Up to like & getrecommendations! Published in 2020 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.0c00127
Abstract: Ricin toxin A subunit (RTA) removes an adenine from the universally conserved sarcin/ricin loop (SRL) on eukaryotic ribosomes thereby inhibiting protein synthesis. No high affinity and selective small-molecule therapeutic antidotes have been reported against ricin… read more here.
Keywords: molecule; ricin; small molecule; rta ... See more keywords
The low density receptor-related protein 1 plays a significant role in ricin-mediated intoxication of lung cells
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-65982-2
Abstract: Ricin, a highly lethal plant-derived toxin, is a potential biological threat agent due to its high availability, ease of production and the lack of approved medical countermeasures for post-exposure treatment. To date, no specific ricin… read more here.
Keywords: ricin; intoxication; receptor related; lrp1 ... See more keywords
Pathophysiological profile of awake and anesthetized pigs following systemic exposure to the highly lethal ricin toxin.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical toxicology"
DOI: 10.1080/15563650.2021.1933513
Abstract: Ricin, a plant-derived toxin originating from the seeds of Ricinus communis (castor bean plant), is one of the most lethal toxins known. To date, no in-depth study of systemic exposure to ricin in a standardized… read more here.
Keywords: following systemic; ricin; exposure; exposure ricin ... See more keywords
Rescue of rhesus macaques from the lethality of aerosolized ricin toxin.
Sign Up to like & getrecommendations! Published in 2019 at "JCI insight"
DOI: 10.1172/jci.insight.124771
Abstract: Ricin toxin (RT) ranks at the top of the list of bioweapons of concern to civilian and military personnel alike, due to its high potential for morbidity and mortality after inhalation. In nonhuman primates, aerosolized… read more here.
Keywords: ricin; aerosolized ricin; rhesus macaques; toxin ... See more keywords
Boron-doped carbon nanowalls for fast and direct detection of cytochrome C and ricin by matrix-free laser desorption/ionization mass spectrometry.
Sign Up to like & getrecommendations! Published in 2022 at "Talanta"
DOI: 10.2139/ssrn.4126943
Abstract: Detecting proteins via surface assisted laser desorption/ionization mass spectrometry (SALDI-MS) method is still highly challenging, and only few examples of nanomaterials have been demonstrated to perform such detection so far. In this study, carbon nanowalls… read more here.
Keywords: carbon nanowalls; laser desorption; ricin; detection ... See more keywords
Computational design of fusion proteins against ErbB2-amplified tumors inspired by ricin toxin
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2023.1098365
Abstract: Although the anti-cancer activity of ricin is well-known, its non-specific targeting challenges the development of ricin-derived medicines. In the present study, novel potential ribosome-inactivating fusion proteins (RIPs) were computationally engineered by incorporation of an ErbB2-dependant… read more here.
Keywords: proteins erbb2; fusion proteins; design fusion; ricin ... See more keywords
An Electrochemical Approach to Follow and Evaluate the Kinetic Catalysis of Ricin on hsDNA
Sign Up to like & getrecommendations! Published in 2021 at "Life"
DOI: 10.3390/life11050405
Abstract: International authorities classify the ricin toxin, present in castor seeds, as a potential agent for use in bioterrorism. Therefore, the detection, identification, and characterization of ricin are considered the first actions for its risk assessment… read more here.
Keywords: ricin; follow evaluate; approach follow; evaluate kinetic ... See more keywords
A New Method for Extraction and Analysis of Ricin Samples through MALDI-TOF-MS/MS
Sign Up to like & getrecommendations! Published in 2019 at "Toxins"
DOI: 10.3390/toxins11040201
Abstract: We report for the first time the efficient use of accelerated solvent extraction (ASE) for extraction of ricin to analytical purposes, followed by the combined use of sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), Matrix-assisted laser… read more here.
Keywords: extraction; ricin; method; maldi tof ... See more keywords