Rictor promotes tumor progression of rapamycin-insensitive triple-negative breast cancer cells.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.08.012
Abstract: Triple-negative breast cancer (TNBC), characterized by decreased expression of hormone receptors and human epidermal growth factor type 2 receptor, has poor prognosis and lacks effective therapeutics. Recently, the mTOR inhibitor rapamycin and its analogs have… read more here.
Keywords: rictor; negative breast; breast cancer; rapamycin insensitive ... See more keywords
mTORC2/Rictor is essential for coelomocyte endocytosis in Apostichopus japonicus.
Sign Up to like & getrecommendations! Published in 2021 at "Developmental and comparative immunology"
DOI: 10.1016/j.dci.2021.104000
Abstract: Endocytosis plays an important role in the immune defence systems of invertebrates through the interaction between the mechanical target of rapamycin complex 2 (mTORC2) and the AGC kinase family. Rictor is the most important unique… read more here.
Keywords: rictor; apostichopus japonicus; coelomocyte endocytosis; mtorc2 rictor ... See more keywords
Correlation between immunohistochemistry and RICTOR FISH amplification in small cell lung carcinoma.
Sign Up to like & getrecommendations! Published in 2019 at "Human pathology"
DOI: 10.1016/j.humpath.2019.08.018
Abstract: Small cell lung carcinoma (SCLC) accounts for approximately 15% of all lung cancers and remains a challenging disease, with no significant improvement in the field of targeted therapies. The RICTOR gene (rapamycin-insensitive companion of mTOR… read more here.
Keywords: rictor; ihc; rictor fish; phospho akt ... See more keywords
Rictor/mTORC2 deficiency enhances keratinocyte stress tolerance via mitohormesis
Sign Up to like & getrecommendations! Published in 2017 at "Cell Death and Differentiation"
DOI: 10.1038/cdd.2017.8
Abstract: How metabolic pathways required for epidermal tissue growth and remodeling influence the ability of keratinocytes to survive stressful conditions is still largely unknown. The mechanistic target of rapamycin complex 2 (mTORC2) regulates growth and metabolism… read more here.
Keywords: rictor; via mitohormesis; stress tolerance; deficiency ... See more keywords
Rictor has a pivotal role in maintaining quiescence as well as stemness of leukemia stem cells in MLL-driven leukemia
Sign Up to like & getrecommendations! Published in 2017 at "Leukemia"
DOI: 10.1038/leu.2016.223
Abstract: Little is known about the roles of Rictor/mTORC2 in the leukemogenesis of acute myeloid leukemia. Here, we demonstrated that Rictor is essential for the maintenance of mixed lineage leukemia (MLL)-driven leukemia by preventing leukemia stem… read more here.
Keywords: rictor; quiescence; mll driven; leukemia ... See more keywords
An RNA–RNA crosstalk network involving HMGB1 and RICTOR facilitates hepatocellular carcinoma tumorigenesis by promoting glutamine metabolism and impedes immunotherapy by PD-L1+ exosomes activity
Sign Up to like & getrecommendations! Published in 2021 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-021-00801-2
Abstract: Hepatocellular carcinoma (HCC) is the global leading cause of cancer-related deaths due to the deficiency of targets for precision therapy. A new modality of epigenetic regulation has emerged involving RNA–RNA crosstalk networks where two or… read more here.
Keywords: rna rna; rictor; hmgb1; crosstalk ... See more keywords
Rictor/mTORC2 involves mitochondrial function in ES cells derived cardiomyocytes via mitochondrial Connexin 43.
Sign Up to like & getrecommendations! Published in 2020 at "Acta pharmacologica Sinica"
DOI: 10.1038/s41401-020-00591-3
Abstract: Rictor is a key component of the mammalian target of rapamycin complex 2 (mTORC2) and is required for Akt phosphorylation (Ser473). Our previous study shows that knockdown of Rictor prevents cardiomyocyte differentiation from mouse embryonic stem… read more here.
Keywords: mitochondrial function; derived cardiomyocytes; knockdown rictor; rictor ... See more keywords
Site-specific activity of mTORC2 in regulating renal K+ secretion to maintain ion homeostasis
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5735093
Abstract: Background: The kinase, mTOR complex-2 (mTORC2), is implicated in the regulation of renal K+ secretion and maintenance of renal sodium and potassium homeostasis. Recent evidences suggest differential regulation of epithelial sodium channel, ENaC, and ENaC-dependent… read more here.
Keywords: mtorc2; renal secretion; rictor; physiology ... See more keywords
Abstract 2706: Therapeutic silencing of Rictor using siRNA nanoparticles to selectively block mTORC2 signaling in triple negative breast cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2706
Abstract: Triple negative breast cancers (TNBCs) are aggressive malignancies with a high rate of recurrence even after neoadjuvant chemotherapy (NAC) and resection. Nearly 50% of NAC-treated TNBC patients harboring residual disease display mutations in the phosphatidyl… read more here.
Keywords: triple negative; rictor; tnbc; tumor ... See more keywords
RICTOR Amplification Promotes NSCLC Cell Proliferation through Formation and Activation of mTORC2 at the Expense of mTORC1
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Cancer Research"
DOI: 10.1158/1541-7786.mcr-20-0262
Abstract: Non–small cell lung cancer (NSCLC) is characterized by genomic alterations, yet a targetable mutation has not been discovered in nearly half of all patients. Recent studies have identified amplification of RICTOR, an mTORC2-specific cofactor, as… read more here.
Keywords: mtorc2; rictor; proliferation; mtorc1 ... See more keywords
Increases in Integrin-ILK-RICTOR-Akt Proteins, Muscle Mass, and Strength after Eccentric Cycling Training.
Sign Up to like & getrecommendations! Published in 2021 at "Medicine and science in sports and exercise"
DOI: 10.1249/mss.0000000000002778
Abstract: PURPOSE Recently it has been suggested that a cellular pathway composed of integrin, integrin-linked kinase (ILK), rapamycin-insensitive companion of mTOR (RICTOR), and Akt may facilitate long-term structural and functional adaptations associated with exercise, independent of… read more here.
Keywords: rictor akt; eccentric cycling; mass; ilk ... See more keywords