RICTOR Amplification Promotes NSCLC Cell Proliferation through Formation and Activation of mTORC2 at the Expense of mTORC1
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Cancer Research"
DOI: 10.1158/1541-7786.mcr-20-0262
Abstract: Non–small cell lung cancer (NSCLC) is characterized by genomic alterations, yet a targetable mutation has not been discovered in nearly half of all patients. Recent studies have identified amplification of RICTOR, an mTORC2-specific cofactor, as… read more here.
Keywords: mtorc2; rictor; proliferation; mtorc1 ... See more keywords
RICTOR amplification identifies a subgroup in small cell lung cancer and predicts response to drugs targeting mTOR
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.13362
Abstract: Small cell lung cancer (SCLC) is an aggressive cancer that represents ~15% of all lung cancers. Currently there are no targeted therapies to treat SCLC. Our genomic analysis of a metastatic SCLC cohort identified recurrent… read more here.
Keywords: rictor; rictor amplification; cancer; cell ... See more keywords