Human RIF1-Protein Phosphatase 1 Prevents Degradation and Breakage of Nascent DNA on Replication Stalling
Sign Up to like & getrecommendations! Published in 2019 at "Cell Reports"
DOI: 10.1016/j.celrep.2019.05.002
Abstract: Summary RIF1 is a multifunctional protein implicated in controlling DNA replication and repair. Here, we show that human RIF1 protects nascent DNA from over-degradation at stalled replication forks. The major nuclease resecting nascent DNA in… read more here.
Keywords: degradation; rif1; dna; nascent dna ... See more keywords
Mouse Rif1 is a regulatory subunit of protein phosphatase 1 (PP1)
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-01910-1
Abstract: Rif1 is a conserved protein that plays essential roles in orchestrating DNA replication timing, controlling nuclear architecture, telomere length and DNA repair. However, the relationship between these different roles, as well as the molecular basis… read more here.
Keywords: protein; rif1; pp1; mouse rif1 ... See more keywords
Rif1 promotes association of G-quadruplex (G4) by its specific G4 binding and oligomerization activities
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-44736-9
Abstract: Rif1 is a conserved protein regulating replication timing and binds preferentially to the vicinity of late-firing/dormant origins in fission yeast. The Rif1 binding sites on the fission yeast genome have an intrinsic potential to generate… read more here.
Keywords: rif1; promotes association; binding oligomerization; rif1 promotes ... See more keywords
A CDK-Dependent Phosphorylation of a Novel Domain of Rif1 Regulates its Function during Telomere Damage and Other Types of Stress
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DOI: 10.1080/10985549.2023.2193768
Abstract: Abstract Rif1 mediates telomere length, DNA replication, and DNA damage responses in budding yeast. Previous work identified several posttranslational modifications of Rif1, however none of these was shown to mediate the molecular or cellular responses… read more here.
Keywords: cdk dependent; telomere damage; rif1; domain ... See more keywords
Rif1 promotes a repressive chromatin state to safeguard against endogenous retrovirus activation
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DOI: 10.1093/nar/gkx884
Abstract: Abstract Transposable elements, including endogenous retroviruses (ERVs), constitute a large fraction of the mammalian genome. They are transcriptionally silenced during early development to protect genome integrity and aberrant transcription. However, the mechanisms that control their… read more here.
Keywords: rif1; chromatin state; promotes repressive; activation ... See more keywords
circACTG1 Promotes Hepatocellular Carcinoma Progression by Regulating miR-940/RIF1 Axis and Activating AKT/mTOR Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Immunology Research"
DOI: 10.1155/2022/8649386
Abstract: Background Hepatocellular carcinoma (HCC) is recognized as the fourth in incidence and the third in mortality worldwide. The onset of HCC is insidious and often asymptomatic at the early stage. HCC is more prone to… read more here.
Keywords: hcc; mir 940; circactg1; akt mtor ... See more keywords
Downregulation of RIF1 Enhances Sensitivity to Platinum-Based Chemotherapy in Epithelial Ovarian Cancer (EOC) by Regulating Nucleotide Excision Repair (NER) Pathway
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000489418
Abstract: Background/Aims: Rap1 interacting factor 1 (RIF1) was deemed to be involved in replication timing regulation and DNA damage response. However, little is known about the role of RIF1 in malignancies. Thus, this study aimed to… read more here.
Keywords: rif1; platinum based; response; based chemotherapy ... See more keywords
RIF1 controls replication initiation and homologous recombination repair in a radiation dose-dependent manner
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DOI: 10.1242/jcs.240036
Abstract: ABSTRACT RIF1 controls both DNA replication timing and the DNA double-strand break (DSB) repair pathway to maintain genome integrity. However, it remains unclear how RIF1 links these two processes following exposure to ionizing radiation (IR).… read more here.
Keywords: rif1; homologous recombination; dose dependent; recombination repair ... See more keywords