Rif1 promotes association of G-quadruplex (G4) by its specific G4 binding and oligomerization activities
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-44736-9
Abstract: Rif1 is a conserved protein regulating replication timing and binds preferentially to the vicinity of late-firing/dormant origins in fission yeast. The Rif1 binding sites on the fission yeast genome have an intrinsic potential to generate… read more here.
Keywords: rif1; promotes association; binding oligomerization; rif1 promotes ... See more keywords
Rif1 promotes a repressive chromatin state to safeguard against endogenous retrovirus activation
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx884
Abstract: Abstract Transposable elements, including endogenous retroviruses (ERVs), constitute a large fraction of the mammalian genome. They are transcriptionally silenced during early development to protect genome integrity and aberrant transcription. However, the mechanisms that control their… read more here.
Keywords: rif1; chromatin state; promotes repressive; activation ... See more keywords