A novel ceftazidime/avibactam, rifabutin, tedizolid and moxifloxacin (CARTM) regimen for pulmonary Mycobacterium avium disease
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkx307
Abstract: Objectives To compare the efficacy of ceftazidime/avibactam plus tedizolid-based combination regimens with the standard therapy of azithromycin, ethambutol and rifabutin for the treatment of pulmonary Mycobacterium avium complex (MAC) disease. Methods We mimicked the human… read more here.
Keywords: ceftazidime avibactam; rifabutin; tedizolid moxifloxacin; mac ... See more keywords
Intraocular deposits and cataracts after long-term rifabutin intake
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DOI: 10.1097/md.0000000000020049
Abstract: Abstract Rationale: Rifabutin is a broad-spectrum antibiotic known to cause deposits on the corneal endothelium and lens. We report a patient in whom cataracts developed and progressive pigment deposits were seen on the corneal endothelium,… read more here.
Keywords: intraocular deposits; rifabutin intake; term rifabutin; long term ... See more keywords
Drug‐level change and optimal dose adjustment of tacrolimus with the use of rifabutin for treating mycobacterial disease in solid organ transplant recipients
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DOI: 10.1111/tid.13893
Abstract: Little is known about the change in drug level and the need for dose adjustment of calcineurin inhibitor when it is used with rifabutin in solid organ transplant (SOT) recipients. We aimed to analyze whether… read more here.
Keywords: rifabutin; tacrolimus; adjustment; drug ... See more keywords
Rifabutin Is Bactericidal against Intracellular and Extracellular Forms of Mycobacterium abscessus
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DOI: 10.1128/aac.00363-20
Abstract: Mycobacterium abscessus is increasingly recognized as an emerging opportunistic pathogen causing severe lung diseases. As it is intrinsically resistant to most conventional antibiotics, there is an unmet medical need for effective treatments. Repurposing of clinically… read more here.
Keywords: rfb; mycobacterium abscessus; abscessus; intracellular extracellular ... See more keywords
Differential Impact of the rpoB Mutant on Rifampin and Rifabutin Resistance Signatures of Mycobacterium tuberculosis Is Revealed Using a Whole-Genome Sequencing Assay
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DOI: 10.1128/spectrum.00754-22
Abstract: Current approaches to diagnose drug-resistant MTB are time-consuming, consequently leading to inefficient intervention or further disease transmission. In this study, we curated lists of coding variants associated with differential rifampin and rifabutin resistant signatures using… read more here.
Keywords: time; rifampin rifabutin; rifabutin; mtb ... See more keywords
Comparison of Compartmental and Non-Compartmental Analysis to Detect Biopharmaceutical Similarity of Intravenous Nanomaterial-Based Rifabutin Formulations
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DOI: 10.3390/pharmaceutics15041258
Abstract: Pharmacometric analysis is often used to quantify the differences and similarities between formulation prototypes. In the regulatory framework, it plays a significant role in the evaluation of bioequivalence. While non-compartmental analysis provides an unbiased data… read more here.
Keywords: albumin stabilized; rifabutin; nanomaterial based; analysis ... See more keywords
Rifabutin as salvage therapy for Helicobacter pylori eradication: Cornerstones and novelties
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DOI: 10.3748/wjg.v28.i45.6356
Abstract: When several Helicobacter pylori eradication treatments fail, guidelines recommend a cultured guided approach; however, culture is not widely available. Therefore, a rifabutin based regimen could be the best solution. Rifabutin indeed shows a low rate… read more here.
Keywords: pylori eradication; therapy; rifabutin; eradication ... See more keywords