Bacterial Outer Membrane‐Coated Mesoporous Silica Nanoparticles for Targeted Delivery of Antibiotic Rifampicin against Gram‐Negative Bacterial Infection In Vivo
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202103442
Abstract: The efficacy of conventional antibiotics therapeutics has declined rapidly due to the emerged antibiotic resistance. There is an urgent need to develop novel approaches to address the problem of antibiotic shortage, particularly for Gram‐negative bacteria.… read more here.
Keywords: msn omv; rifampicin; outer membrane; gram ... See more keywords
Physiologically based pharmacokinetic modeling characterizes the drug-drug interaction between saxagliptin and rifampicin in patients with renal impairment.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of clinical pharmacology"
DOI: 10.1002/jcph.2223
Abstract: The aim of the present study is to develop physiologically based pharmacokinetic (PBPK) models for saxagliptin and its active metabolite, 5-hydroxy saxagliptin, and to predict the effect of co-administration of rifampicin, a strong inducer of… read more here.
Keywords: hydroxy saxagliptin; renal impairment; rifampicin; drug ... See more keywords
Continuous preparation for rifampicin
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Flow Chemistry"
DOI: 10.1007/s41981-018-0017-2
Abstract: To reduce the cost and improve the efficiency for rifampicin preparation, a continuous flow synthesis of rifampicin starting from rifamycin S and tert-butylamine was studied in a microreactor. Two reaction steps and one purification step… read more here.
Keywords: rifampicin; chemistry; preparation rifampicin; continuous preparation ... See more keywords
Rifampicin ameliorates lithium‐pilocarpine‐induced seizures, consequent hippocampal damage and memory deficit in rats: Impact on oxidative, inflammatory and apoptotic machineries
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2018.09.004
Abstract: Graphical abstract Figure. No Caption available. Abstract Epilepsy is one of the serious neurological sequelae of bacterial meningitis. Rifampicin, the well‐known broad spectrum antibiotic, is clinically used for chemoprophylaxis of meningitis. Besides its antibiotic effects,… read more here.
Keywords: meningitis; rifampicin; rifampicin pretreatment; inflammatory ... See more keywords
Pharmacokinetics of dolutegravir 100 mg once daily with rifampicin.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2019.04.009
Abstract: BACKGROUND Tuberculosis (TB) causes 25% of all deaths among individuals infected with human immunodeficiency virus (HIV). Rifampicin (RIF) is a potent inducer of drug metabolizing enzymes and drug transporters, and co-administration with dolutegravir (DTG) reduces… read more here.
Keywords: rifampicin; 100 daily; dtg 100; c24h ... See more keywords
Rifampicin as a novel tyrosinase inhibitor: Inhibitory activity and mechanism.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2017.04.058
Abstract: In this study, the inhibitory effect and mechanism of rifampicin on the activity of tyrosinase were investigated for developing a novel tyrosinase inhibitor. It was found to have a significant inhibition on the activity of… read more here.
Keywords: rifampicin; tyrosinase inhibitor; novel tyrosinase; tyrosinase ... See more keywords
Co-spray drying of hygroscopic kanamycin with the hydrophobic drug rifampicin to improve the aerosolization of kanamycin powder for treating respiratory infections.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2018.02.026
Abstract: High dose delivery of drugs to the lung using a dry powder inhaler (DPI) is an emerging approach to combat drug-resistant local infections. To achieve this, highly aerosolizable powders are required. We hypothesized that co-spray-drying… read more here.
Keywords: rifampicin; spray drying; aerosolization kanamycin; drug ... See more keywords
Solidified SNEDDS for the oral delivery of rifampicin: Evaluation, proof of concept, in vivo kinetics, and in silico GastroPlusTM simulation.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2019.05.061
Abstract: The present investigation was performed to develop a rifampicin (RIF)-loaded solidified self-nanoemulsifying drug delivery system (SNEDDS) (solidified RIF-OF1) for in vitro and in vivo evaluations. Optimized formulations were tested for their powder flow characteristics, loading… read more here.
Keywords: rifampicin; vivo; delivery; gastroplustm simulation ... See more keywords
Sensitivity and specificity of the mean corpuscular volume and CD4/CD8 ratio in discriminating between rifampicin resistant and rifampicin sensitive tuberculosis
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DOI: 10.1016/j.jctube.2020.100205
Abstract: Background There is need for simple, cost effective and widely available point of care tests for low level health facilities in developing countries to screen for drug resistant tuberculosis (TB) after bacteriological confirmation of TB… read more here.
Keywords: rifampicin; tuberculosis; cd4 cd8; sensitivity specificity ... See more keywords
Sequencing of the entire rpob gene characterization of mutations in isolates of Mycobacterium tuberculosis circulating in an endemic tuberculosis setting.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of global antimicrobial resistance"
DOI: 10.1016/j.jgar.2019.03.001
Abstract: OBJECTIVE To evaluate the utility of a sequencing procedure for the entire rpoB gene of Mycobacterium tuberculosis to identify mutations pre, within and post rifampicin resistance determinant region (RRDR) in isolates circulating in a region… read more here.
Keywords: rpob gene; rifampicin; tuberculosis; entire rpob ... See more keywords
Mode of Action of Kanglemycin A, an Ansamycin Natural Product that Is Active against Rifampicin-Resistant Mycobacterium tuberculosis
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DOI: 10.1016/j.molcel.2018.08.028
Abstract: Summary Antibiotic-resistant bacterial pathogens pose an urgent healthcare threat, prompting a demand for new medicines. We report the mode of action of the natural ansamycin antibiotic kanglemycin A (KglA). KglA binds bacterial RNA polymerase at… read more here.
Keywords: rifampicin; resistant mycobacterium; rna polymerase; rifampicin resistant ... See more keywords