Effects of rifampicin on antineoplastic drug pyrotinib maleate pharmacokinetics in healthy subjects
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DOI: 10.1007/s10637-022-01241-7
Abstract: Pyrotinib (PTN), an irreversible EGFR/HER2 dual tyrosine kinase inhibitor used for treating HER2-positive breast cancer, is primarily metabolized by cytochrome P450 (CYP)3A4 isozyme. Rifampicin (RIF) is a strong index CYP3A4 inducer. Therefore, the study aimed… read more here.
Keywords: pyrotinib; study; rif; rifampicin antineoplastic ... See more keywords