Mutations compensating for the fitness cost of rifampicin resistance in Escherichia coli exert pleiotropic effect on RNA polymerase catalysis
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac406
Abstract: Abstract The spread of drug-resistant bacteria represents one of the most significant medical problems of our time. Bacterial fitness loss associated with drug resistance can be counteracted by acquisition of secondary mutations, thereby enhancing the… read more here.
Keywords: rifampicin resistance; rna polymerase; resistance; fitness ... See more keywords
False Rifampicin Resistance in Xpert Ultra Applied to Lymph Node Aspirate: A Case Report
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DOI: 10.1093/ofid/ofaa204
Abstract: Abstract A 36-year-old male patient was diagnosed with tuberculosis in Antwerp, Belgium, in May 2018. His lymph node aspirate initially tested rifampicin resistant in Xpert MTB/RIF Ultra, but tested susceptible in all other tests including… read more here.
Keywords: resistance xpert; node aspirate; false rifampicin; xpert ... See more keywords
Rifampicin resistance in mycobacterium tuberculosis patients using GeneXpert at Livingstone Central Hospital for the year 2015: a cross sectional explorative study
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DOI: 10.1186/s12879-017-2750-9
Abstract: BackgroundSince the recent introduction of GeneXepert for the detection of Tuberculosis (TB) drug resistance mutations in both primary resistance and acquired resistance in Zambia, little has been documented in literature on the issue of rifampicin… read more here.
Keywords: central hospital; study; livingstone central; resistance ... See more keywords
Age and sex distribution of Mycobacterium tuberculosis infection and rifampicin resistance in Myanmar as detected by Xpert MTB/RIF
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DOI: 10.1186/s12879-021-06296-0
Abstract: Background Detection of tuberculosis disease (TB) and timely identification of Mycobacterium tuberculosis ( Mtb ) strains that are resistant to treatment are key to halting tuberculosis transmission, improving treatment outcomes, and reducing mortality. Methods We… read more here.
Keywords: age; rifampicin resistance; tuberculosis; mtb ... See more keywords
Trends of Mycobacterium tuberculosis and rifampicin resistance in Adigrat General Hospital, Eastern zone of Tigrai, North Ethiopia
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DOI: 10.1186/s40794-020-00115-1
Abstract: Tuberculosis is an infectious disease usually caused by Mycobacterium tuberculosis bacteria. The global emergence of mono- or multidrug-resistant tuberculosis and extensively drug-resistant forms of tuberculosis pose a considerable challenge to tuberculosis control programs. There has… read more here.
Keywords: hospital; tuberculosis; resistance; rifampicin resistance ... See more keywords
Detection of Mycobacterium tuberculosis and rifampicin resistance by Xpert® MTB/RIF assay among presumptive tuberculosis cases at Jimma University Medical Center, Southwest Ethiopia
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DOI: 10.1371/journal.pone.0262929
Abstract: Background Rapid diagnosis of tuberculosis (TB) and detection of drug resistance are very important for timely and appropriate management of patients. Xpert MTB/RIF assay is approved for use in TB and rifampicin-resistance diagnosis. However, data… read more here.
Keywords: rifampicin resistance; mtb rif; tuberculosis; rif assay ... See more keywords
Prevalence, Associated Risk Factors and Rifampicin Resistance Pattern of Pulmonary Tuberculosis Among Children at Debre Markos Referral Hospital, Northwest, Ethiopia
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DOI: 10.2147/idr.s277222
Abstract: Background Tuberculosis presents a heightened threat to community health throughout the world but disproportionately afflicts low-income nations. In Ethiopia, TB is a significant health problem in children causing significant morbidity and mortality. Therefore, this study… read more here.
Keywords: pulmonary tuberculosis; rifampicin resistance; resistance; risk factors ... See more keywords
HIV-Negative Rifampicin Resistance/Multidrug-Resistant Extrapulmonary Tuberculosis in China from 2015 to 2019: A Clinical Retrospective Investigation Study from a National Tuberculosis Clinical Research Center
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DOI: 10.2147/idr.s342744
Abstract: Background China is the region with a high global burden of rifampicin resistance/multidrug-resistant tuberculosis (RR/MDR-TB) and low HIV incidence. Our aim was to assess the clinical and demographic characteristics of RR/MDR-extrapulmonary tuberculosis (EPTB) from 2015… read more here.
Keywords: multidrug resistant; extrapulmonary tuberculosis; rifampicin resistance; resistance ... See more keywords
Detection of Mycobacterium tuberculosis Rifampicin Resistance Conferred by Borderline rpoB Mutations: Xpert MTB/RIF is Superior to Phenotypic Drug Susceptibility Testing
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DOI: 10.2147/idr.s358301
Abstract: Objective To compare the ability of detection of borderline rifampicin resistance in Mycobacterium tuberculosis between molecular assay and phenotypic drug susceptibility tests. Methods Fifty-seven isolates with His445Leu, Asp435Tyr, Leu452Pro, Leu430Pro, His445Asn, Ile491Phe, and His445Ser mutations… read more here.
Keywords: rifampicin resistance; mtb rif; resistance; rifampicin ... See more keywords
Alterations in the Spectrum of Spontaneous Rifampicin-Resistance Mutations in the Bacillus subtilis rpoB Gene after Cultivation in the Human Spaceflight Environment
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DOI: 10.3389/fmicb.2018.00192
Abstract: The effect of Bacillus subtilis exposure to the human spaceflight environment on growth, mutagenic frequency, and spectrum of mutations to rifampicin resistance (RifR) was investigated. B. subtilis cells were cultivated in Biological Research in Canister-Petri… read more here.
Keywords: spaceflight environment; rpob gene; human spaceflight; rifampicin resistance ... See more keywords
Rifampicin resistance patterns and dynamics of tuberculosis and drug-resistant tuberculosis in Enugu, South Eastern Nigeria.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of infection in developing countries"
DOI: 10.3855/jidc.12736
Abstract: INTRODUCTION Tuberculosis (TB) continues to be a public health problem globally. The burden is further exacerbated in developing countries like Nigeria, by poor diagnosis, management and treatment, as well as rapid emergence of drug-resistant TB.… read more here.
Keywords: drug; drug resistant; tuberculosis; resistance ... See more keywords