Outcomes of a nine-month regimen for rifampicin-resistant tuberculosis up to 24 months after treatment completion in nine African countries
Sign Up to like & getrecommendations! Published in 2020 at "EClinicalMedicine"
DOI: 10.1016/j.eclinm.2020.100268
Abstract: Background Treatment outcomes of the shorter regimen for rifampicin-resistant tuberculosis are not completely established. We report on these outcomes two years after treatment completion among patients enrolled in an observational cohort study in nine African… read more here.
Keywords: regimen rifampicin; treatment; rifampicin resistant; treatment completion ... See more keywords
WHO 2018 treatment guidelines for rifampicin-resistant tuberculosis: uncertainty, potential risks and the way forward.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2019.10.003
Abstract: The 2018 World Health Organization (WHO) treatment guidelines for multidrug-/rifampicin-resistant tuberculosis (MDR/RR-TB) give preference to all-oral long regimens for 18-20 months. The document strongly recommends combining bedaquiline, levofloxacin (or moxifloxacin) and linezolid, supplemented by cycloserine… read more here.
Keywords: mdr; treatment; rifampicin resistant; tuberculosis ... See more keywords
Mode of Action of Kanglemycin A, an Ansamycin Natural Product that Is Active against Rifampicin-Resistant Mycobacterium tuberculosis
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cell"
DOI: 10.1016/j.molcel.2018.08.028
Abstract: Summary Antibiotic-resistant bacterial pathogens pose an urgent healthcare threat, prompting a demand for new medicines. We report the mode of action of the natural ansamycin antibiotic kanglemycin A (KglA). KglA binds bacterial RNA polymerase at… read more here.
Keywords: rifampicin; resistant mycobacterium; rna polymerase; rifampicin resistant ... See more keywords
A highly rifampicin resistant Mycobacterium tuberculosis strain emerging in Southern Brazil.
Sign Up to like & getrecommendations! Published in 2020 at "Tuberculosis"
DOI: 10.1016/j.tube.2020.102015
Abstract: Here we described phenotypical, molecular and epidemiological features of a highly rifampicin-resistant Mycobacterium tuberculosis strain emerging in Southern Brazil, that carries an uncommon insertion of 12 nucleotides at the codon 435 in the rpoB gene.… read more here.
Keywords: resistant mycobacterium; rifampicin resistant; tuberculosis; strain ... See more keywords
Rapid and Ultrasensitive Approach for the Simultaneous Detection of Multilocus Mutations to Distinguish Rifampicin-Resistant Mycobacterium tuberculosis.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c04399
Abstract: The untested empirical medications exacerbated the development of multidrug-resistant Mycobacterium tuberculosis (MDR-TB). Here, we develop a rapid and specific method based on loop-mediated isothermal amplification and duplex-specific nuclease for distinguishing rifampicin-resistant M. tuberculosis. Three probes… read more here.
Keywords: rifampicin resistant; tuberculosis; detection; resistant mycobacterium ... See more keywords
Linezolid-related adverse effects in the treatment of rifampicin resistant tuberculosis: a retrospective study.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemotherapy"
DOI: 10.1080/1120009x.2022.2136447
Abstract: Linezolid (LZD) is an effective drug in treating multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis. This study aimed to evaluate the safety of LZD in the treatment of patients with rifampicin resistant tuberculosis. This was a… read more here.
Keywords: rifampicin resistant; tuberculosis; resistant tuberculosis; risk ... See more keywords
Pharmacokinetics and Dose Optimization Strategies of Para-Aminosalicylic Acid in Children with Rifampicin-Resistant Tuberculosis
Sign Up to like & getrecommendations! Published in 2022 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.02264-21
Abstract: Treatment options for children with Rifampicin-resistant tuberculosis (RR-TB) remain limited, and para-aminosalicylic acid (PAS) is still a relevant component of treatment regimens. Prevention of resistance to companion drugs by PAS is dose related, and at… read more here.
Keywords: pas; rifampicin resistant; para aminosalicylic; children rifampicin ... See more keywords
Whole-Genome Sequencing Has the Potential To Improve Treatment for Rifampicin-Resistant Tuberculosis in High-Burden Settings: a Retrospective Cohort Study
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Microbiology"
DOI: 10.1128/jcm.02362-21
Abstract: Treatment of multidrug-resistant or rifampicin-resistant tuberculosis (MDR/RR-TB), although improved in recent years with shorter, more tolerable regimens, remains largely standardized and based on limited drug susceptibility testing (DST). More individualized treatment with expanded DST access… read more here.
Keywords: treatment; resistant tuberculosis; drug; rifampicin resistant ... See more keywords
Ongoing challenges to understanding multidrug- and rifampicin-resistant tuberculosis in children versus adults
Sign Up to like & getrecommendations! Published in 2020 at "European Respiratory Journal"
DOI: 10.1183/13993003.02504-2020
Abstract: Previous analyses suggest that children with tuberculosis (TB) are no more or no less likely to have multidrug (MDR)- or rifampicin-resistant (RR)-TB than adults. However, the availability of new data, particularly for high MDR/RR-TB burden… read more here.
Keywords: multidrug; challenges understanding; rifampicin resistant; tuberculosis ... See more keywords
Rifampicin-resistant tuberculosis in Singapore, 2005 to 2018
Sign Up to like & getrecommendations! Published in 2019 at "Tuberculosis"
DOI: 10.1183/13993003.congress-2019.pa5282
Abstract: Background: Globally, about 80% of rifampicin-resistant (RR) tuberculosis (TB) are also resistant to isoniazid. Thus, it is taken as a surrogate marker of multi-drug resistant (MDR) TB. Aim: The objective of this study is to… read more here.
Keywords: treatment; rifampicin resistant; tuberculosis; singapore ... See more keywords
High rates of death and loss to follow-up by 12 months of rifampicin resistant TB treatment in South Africa
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0205463
Abstract: Introduction Treatment success rates of rifampicin resistant (RR)/multi-drug resistant (MDR) tuberculosis (TB) in South Africa range from 43–48%, falling short of the World Health Organization’s target of ≥75%. We present rates and assess predictors of… read more here.
Keywords: south africa; treatment; rifampicin resistant; loss follow ... See more keywords