Heterodimeric Rifampicin-Tobramycin conjugates break intrinsic resistance of Pseudomonas aeruginosa to doxycycline and chloramphenicol in vitro and in a Galleria mellonella in vivo model.
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DOI: 10.1016/j.ejmech.2019.04.034
Abstract: Intrinsic resistance in Pseudomonas aeruginosa, defined by chromosomally encoded low outer membrane permeability and constitutively over-expressed efflux pumps, is a major reason why the pathogen is refractory to many antibiotics. Herein, we report that heterodimeric… read more here.
Keywords: intrinsic resistance; rifampicin tobramycin; resistance pseudomonas; pseudomonas aeruginosa ... See more keywords