Rox, a Rifamycin Resistance Enzyme with an Unprecedented Mechanism of Action.
Sign Up to like & getrecommendations! Published in 2018 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2018.01.009
Abstract: Rifamycin monooxygenases (Rox) are present in a variety of environmental bacteria and are associated with decomposition of the clinically utilized antibiotic rifampin. Here we report the structure and function of a drug-inducible rox gene from… read more here.
Keywords: resistance enzyme; mechanism; rifamycin; rifamycin resistance ... See more keywords
Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-06587-2
Abstract: Rifamycin antibiotics (Rifs) target bacterial RNA polymerases (RNAPs) and are widely used to treat infections including tuberculosis. The utility of these compounds is threatened by the increasing incidence of resistance (RifR). As resistance mechanisms found… read more here.
Keywords: mechanism; rifamycin; active rifampicin; resistance ... See more keywords
Abstract 1999: Repurposing an antibiotic for breast cancer treatment using liposomes as a delivery system
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1999
Abstract: Purpose: Scientific community is always searching for alternatives for cancer treatment and promoting drug repurposing is one of the ways. Rifamycin is a well-known antibiotic, that inhibits RNA synthesis and probably can be explored as… read more here.
Keywords: breast cancer; rifamycin; drug; cancer treatment ... See more keywords
Characterization of the Rifamycin-Degrading Monooxygenase From Rifamycin Producers Implicating Its Involvement in Saliniketal Biosynthesis
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2020.00971
Abstract: Rifamycin derivatives, such as rifampicin, have potent antibiotic activity and have long been used in the clinic as mainstay components for the treatment of tuberculosis, leprosy, and AIDS-associated mycobacterial infections. However, the extensive usage of… read more here.
Keywords: biosynthesis; degrading monooxygenase; rifamycin degrading; rifamycin producers ... See more keywords
8-Deoxy-Rifamycin Derivatives from Amycolatopsis mediterranei S699 ΔrifT Strain
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DOI: 10.3390/biom10091265
Abstract: Proansamycin X, a hypothetical earliest macrocyclic precursor in the biosynthesis of rifamycin, had never been isolated and identified. According to bioinformatics analysis, it was proposed that RifT (a putative NADH-dependent dehydrogenase) may be a candidate… read more here.
Keywords: deoxy rifamycin; rifamycin; rift; mediterranei s699 ... See more keywords
Stability of Non-Ionic Surfactant Vesicles Loaded with Rifamycin S
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14122626
Abstract: These days, the eradication of bacterial infections is more difficult due to the mechanism of resistance that bacteria have developed towards traditional antibiotics. One of the medical strategies used against bacteria is the therapy with… read more here.
Keywords: surfactant vesicles; ionic surfactant; non ionic; rifamycin ... See more keywords