Direct RIG‐I activation in human NK cells induces TRAIL‐dependent cytotoxicity toward autologous melanoma cells
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DOI: 10.1002/ijc.31874
Abstract: Activation of the innate immune receptor retinoic acid‐inducible gene I (RIG‐I) by its specific ligand 5′‐triphosphate RNA (3pRNA) triggers anti‐tumor immunity, which is dependent on natural killer (NK) cell activation and cytokine induction. However, to… read more here.
Keywords: rig activation; rig; melanoma cells; activation ... See more keywords
FIP200 restricts RNA virus infection by facilitating RIG-I activation
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DOI: 10.1038/s42003-021-02450-1
Abstract: Retinoic acid-inducible gene I (RIG-I) senses viral RNA and instigates an innate immune signaling cascade to induce type I interferon expression. Currently, the regulatory mechanisms controlling RIG-I activation remain to be fully elucidated. Here we… read more here.
Keywords: virus infection; rig activation; rna virus; activation ... See more keywords
A minimal RNA ligand for potent RIG-I activation in living mice
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DOI: 10.1126/sciadv.1701854
Abstract: Short stem-loop RNAs activate RIG-I in mice, activating the innate immune system via specific patterns of gene expression. We have developed highly potent synthetic activators of the vertebrate immune system that specifically target the RIG-I… read more here.
Keywords: rig activation; rig; immune system; rna ligand ... See more keywords
Inhibition of Ongoing Influenza A Virus Replication Reveals Different Mechanisms of RIG-I Activation
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DOI: 10.1128/jvi.02066-18
Abstract: The induction of an IFN response by IAV is mainly mediated by the RNA sensor RIG-I. The physiological RIG-I ligands produced during IAV infection are not fully elucidated. Cellular constraints leading to the inhibition of… read more here.
Keywords: replication; viral rna; rig activation; rna ... See more keywords