SARS‐CoV‐2 NSP7 inhibits type I and III IFN production by targeting the RIG‐I/MDA5, TRIF, and STING signaling pathways
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DOI: 10.1002/jmv.28561
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is a poor inducer of innate antiviral immunity, and the underlying mechanism still needs further investigation. Here, we reported that SARS‐CoV‐2 NSP7 inhibited the production of type I… read more here.
Keywords: type iii; rig mda5; cov nsp7; sars cov ... See more keywords
SARS‐CoV‐2 NSP8 suppresses type I and III IFN responses by modulating the RIG‐I/MDA5, TRIF, and STING signaling pathways
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DOI: 10.1002/jmv.28680
Abstract: SARS‐CoV‐2 has developed a variety of approaches to counteract host innate antiviral immunity to facilitate its infection, replication and pathogenesis, but the molecular mechanisms that it employs are still not been fully understood. Here, we… read more here.
Keywords: type iii; rig mda5; cov nsp8; trif sting ... See more keywords
Replication of Porcine Astrovirus Type 1-Infected PK-15 Cells In Vitro Affected by RIG-I and MDA5 Signaling Pathways
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DOI: 10.1128/spectrum.00701-23
Abstract: Astroviruses (AstVs) are widespread and can infect multiple species. Porcine astroviruses produce mainly gastroenteritis and neurological diseases in pigs. ABSTRACT The interferon (IFN) system is an extremely powerful antiviral response in animal cells. The subsequent… read more here.
Keywords: replication; rig mda5; ifn; pastv1 ... See more keywords
Pseudorabies Virus Tegument Protein UL13 Suppresses RLR-Mediated Antiviral Innate Immunity through Regulating Receptor Transcription
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DOI: 10.3390/v14071465
Abstract: Pseudorabies virus (PRV) has evolved various strategies to escape host antiviral immune responses. However, it remains unclear whether and how PRV-encoded proteins modulate the RIG-I-like receptor (RLR)-mediated signals for immune evasion. Here, we show that… read more here.
Keywords: rlr mediated; transcription; rig mda5; mediated antiviral ... See more keywords