The Coxiella burnetii effector EmcB is a deubiquitinase that inhibits RIG-I signaling.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2217602120
Abstract: Eukaryotes have cytosolic surveillance systems to detect invading microorganisms and initiate protective immune responses. In turn, host-adapted pathogens have evolved strategies to modulate these surveillance systems, which can promote dissemination and persistence in the host.… read more here.
Keywords: surveillance; rig signaling; coxiella burnetii; dot icm ... See more keywords
Aging impairs both primary and secondary RIG-I signaling for interferon induction in human monocytes
Sign Up to like & getrecommendations! Published in 2017 at "Science Signaling"
DOI: 10.1126/scisignal.aan2392
Abstract: Age-related reduction of the adaptor protein TRAF3 compromises the innate immune response of monocytes from older individuals. Aging compromises innate immunity Older adults are more susceptible than younger adults to death resulting from influenza A… read more here.
Keywords: rig; iav; monocytes older; older individuals ... See more keywords
The lncRNAs involved in regulating the RIG-I signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.1041682
Abstract: Understanding the targets and interactions of long non-coding RNAs (lncRNAs) related to the retinoic acid-inducible gene-I (RIG-I) signaling pathway is essential for developing interventions, which would enable directing the host inflammatory response regulation toward protective… read more here.
Keywords: involved regulating; signaling pathway; pathway lncrnas; rig signaling ... See more keywords