Exploring the signaling space of a GPCR using bivalent ligands with a rigid oligoproline backbone.
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DOI: 10.1073/pnas.2108776118
Abstract: G protein-coupled receptors (GPCRs) are one of the most important drug-target classes in pharmaceutical industry. Their diversity in signaling, which can be modulated with drugs, permits the design of more effective and better-tolerated therapeutics. In… read more here.
Keywords: space; exploring signaling; rigid oligoproline; distance ... See more keywords